rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to genes published in J. Neurosci.

PMID	Journal	Published Date	Author	Title
9852565	J. Neurosci.	1998	Castilho RF et al.	Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.
11717342	J. Neurosci.	2001	Chen X et al.	Opioid receptor modulation of a metabolically sensitive ion channel in rat amygdala neurons.
11826108	J. Neurosci.	2002	Gao HM et al.	Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.
12486162	J. Neurosci.	2002	Ryu EJ et al.	Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.
12867501	J. Neurosci.	2003	Gao HM et al.	Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
12177198	J. Neurosci.	2002	Sherer TB et al.	An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage.
19741132	J. Neurosci.	2009	Ng CH et al.	Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
19074024	J. Neurosci.	2008	Rojas JC et al.	Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy.
19625511	J. Neurosci.	2009	Saha S et al.	LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
17687034	J. Neurosci.	2007	Wang C et al.	Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.
17611283	J. Neurosci.	2007	Yadava N and Nicholls DG	Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone.
15574738	J. Neurosci.	2004	Hongpaisan J et al.	Strong calcium entry activates mitochondrial superoxide generation, upregulating kinase signaling in hippocampal neurons.
15673665	J. Neurosci.	2005	Allen NJ et al.	A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells.
16641227	J. Neurosci.	2006	Hsuan SL et al.	Basic fibroblast growth factor protects against rotenone-induced dopaminergic cell death through activation of extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase pathways.
16624952	J. Neurosci.	2006	Jiang Q et al.	Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism.
17005863	J. Neurosci.	2006	Malagelada C et al.	RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation.
18463239	J. Neurosci.	2008	Press C and Milbrandt J	Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.
18685029	J. Neurosci.	2008	Costa C et al.	Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
18716221	J. Neurosci.	2008	Hayashi Y et al.	Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.