PSYCHOSINE
PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.
References related to genes published in J. Neurosci.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 19439584 | J. Neurosci. | 2009 | White AB et al. | Psychosine accumulates in membrane microdomains in the brain of krabbe patients, disrupting the raft architecture. |
| 21734286 | J. Neurosci. | 2011 | Reddy AS et al. | Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. |
| 18077684 | J. Neurosci. | 2007 | Galbiati F et al. | Autonomic denervation of lymphoid organs leads to epigenetic immune atrophy in a mouse model of Krabbe disease. |
| 23761900 | J. Neurosci. | 2013 | Cantuti Castelvetri L et al. | The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3β and deregulation of molecular motors. |