rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to lipids published in J. Neurosci.


PMIDJournalPublished DateAuthorTitle
12598611J. Neurosci.2003Gao HM et al.Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease.
12867501J. Neurosci.2003Gao HM et al.Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.
18685029J. Neurosci.2008Costa C et al.Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.