quercetin

quercetin is a lipid of Polyketides (PK) class. Quercetin is associated with abnormalities such as Coronary heart disease, Myocardial Infarction, Cirrhosis, Coronary Arteriosclerosis and Vascular ring. The involved functions are known as Vasodilation, physiological aspects, Fermentation, Process and Ingredient. Quercetin often locates in Arterial system, Endothelium, Skin, Endothelium, Vascular and Tissue specimen. The associated genes with quercetin are P4HTM gene, SULT gene, UGT1A1 gene, ARHGAP26 gene and PLXNB1 gene. The related lipids are blood lipid, Promega, Steroids, Phosphatidylserines and Fatty Acids. The related experimental models are Knock-out, Mouse Model, Xenograft Model, Tissue Model and Cancer Model.

References related to functions published in J. Nutr.

PMID	Journal	Published Date	Author	Title
9482769	J. Nutr.	1998	Conquer JA et al.	Supplementation with quercetin markedly increases plasma quercetin concentration without effect on selected risk factors for heart disease in healthy subjects.
11238754	J. Nutr.	2001	de Vries JH et al.	Red wine is a poor source of bioavailable flavonols in men.
11584085	J. Nutr.	2001	Walle T et al.	Carbon dioxide is the major metabolite of quercetin in humans.
11823574	J. Nutr.	2002	DuPont MS et al.	Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans.
11435510	J. Nutr.	2001	Sesink AL et al.	Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4'-glucoside.
11925453	J. Nutr.	2002	Wolffram S et al.	Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine.
12221254	J. Nutr.	2002	Arts IC et al.	Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine.
12612140	J. Nutr.	2003	Pal S et al.	Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells.
12888656	J. Nutr.	2003	Mertens-Talcott SU et al.	Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells.
10801919	J. Nutr.	2000	Olthof MR et al.	Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans.
11053503	J. Nutr.	2000	Walle T et al.	Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption.
10958819	J. Nutr.	2000	Arai Y et al.	Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration.
15173420	J. Nutr.	2004	Lesser S et al.	Bioavailability of quercetin in pigs is influenced by the dietary fat content.
15113938	J. Nutr.	2004	Choi JS et al.	Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: role of nuclear factor-kappa B.
21562239	J. Nutr.	2011	Cuevas MJ et al.	Suppression of amphiregulin/epidermal growth factor receptor signals contributes to the protective effects of quercetin in cirrhotic rats.
19056647	J. Nutr.	2009	Warren CA et al.	Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory mediators that influence proliferation and apoptosis.
19494027	J. Nutr.	2009	Tieppo J et al.	Quercetin administration ameliorates pulmonary complications of cirrhosis in rats.
20032478	J. Nutr.	2010	Egert S et al.	Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype.
17951477	J. Nutr.	2007	Edwards RL et al.	Quercetin reduces blood pressure in hypertensive subjects.
17449583	J. Nutr.	2007	Ruiz PA et al.	Quercetin inhibits TNF-induced NF-kappaB transcription factor recruitment to proinflammatory gene promoters in murine intestinal epithelial cells.
17311951	J. Nutr.	2007	Carlstrom J et al.	A quercetin supplemented diet does not prevent cardiovascular complications in spontaneously hypertensive rats.
18424596	J. Nutr.	2008	Wiczkowski W et al.	Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides.
15735102	J. Nutr.	2005	Mertens-Talcott SU et al.	Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.
15795425	J. Nutr.	2005	Enkhmaa B et al.	Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice.
16365056	J. Nutr.	2006	Graf BA et al.	Rat gastrointestinal tissues metabolize quercetin.
14988445	J. Nutr.	2004	de Pascual-Teresa S et al.	Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo.
15930438	J. Nutr.	2005	Martínez-Flórez S et al.	Quercetin attenuates nuclear factor-kappaB activation and nitric oxide production in interleukin-1beta-activated rat hepatocytes.
15987838	J. Nutr.	2005	Percival SS	Commentary on: tissue distribution of quercetin in rats and pigs.
15987855	J. Nutr.	2005	de Boer VC et al.	Tissue distribution of quercetin in rats and pigs.
17056790	J. Nutr.	2006	Granado-Serrano AB et al.	Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2).
17056814	J. Nutr.	2006	Dihal AA et al.	Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats.
16614401	J. Nutr.	2006	Jackson SJ and Venema RC	Quercetin inhibits eNOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells.
16177186	J. Nutr.	2005	Dias AS et al.	Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats.
18492835	J. Nutr.	2008	Amasheh M et al.	Quercetin enhances epithelial barrier function and increases claudin-4 expression in Caco-2 cells.
22535755	J. Nutr.	2012	Panchal SK et al.	Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats.
22915297	J. Nutr.	2012	Marcolin E et al.	Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
23902958	J. Nutr.	2013	Mukai R et al.	Prenylation enhances quercetin uptake and reduces efflux in Caco-2 cells and enhances tissue accumulation in mice fed long-term.
11053519	J. Nutr.	2000	Gee JM et al.	Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway.