DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

References related to functions published in J. Nutr.

PMID	Journal	Published Date	Author	Title
10498759	J. Nutr.	1999	Gee JM et al.	Consumption of fish oil leads to prompt incorporation of eicosapentaenoic acid into colonic mucosa of patients prior to surgery for colorectal cancer, but has no detectable effect on epithelial cytokinetics.
21068183	J. Nutr.	2011	Toufektsian MC et al.	Dietary flavonoids increase plasma very long-chain (n-3) fatty acids in rats.
21525247	J. Nutr.	2011	Escolano-Margarit MV et al.	Prenatal DHA status and neurological outcome in children at age 5.5 years are positively associated.
21525263	J. Nutr.	2011	Rockett BD et al.	Membrane raft organization is more sensitive to disruption by (n-3) PUFA than nonraft organization in EL4 and B cells.
19244379	J. Nutr.	2009	Harris WS et al.	Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.
19022980	J. Nutr.	2008	Lukiw WJ and Bazan NG	Docosahexaenoic acid and the aging brain.
19640970	J. Nutr.	2009	Shaikh SR et al.	Docosahexaenoic acid modifies the clustering and size of lipid rafts and the lateral organization and surface expression of MHC class I of EL4 cells.
19864401	J. Nutr.	2009	Friesen RW and Innis SM	Dietary arachidonic acid to EPA and DHA balance is increased among Canadian pregnant women with low fish intake.
17311938	J. Nutr.	2007	Schley PD et al.	(n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells.
18356340	J. Nutr.	2008	Beli E et al.	Docosahexaenoic acid-enriched fish oil consumption modulates immunoglobulin responses to and clearance of enteric reovirus infection in mice.
15570035	J. Nutr.	2004	Jia Q et al.	Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice.
16251608	J. Nutr.	2005	Yu-Poth S et al.	Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells.
16251623	J. Nutr.	2005	Foran JA et al.	Quantitative analysis of the benefits and risks of consuming farmed and wild salmon.
16424113	J. Nutr.	2006	Jia Q et al.	Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages.
18492846	J. Nutr.	2008	Cohen BE et al.	Red blood cell docosahexaenoic acid and eicosapentaenoic acid concentrations are positively associated with socioeconomic status in patients with established coronary artery disease: data from the Heart and Soul Study.
22623386	J. Nutr.	2012	Harris WS et al.	Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans.
22279134	J. Nutr.	2012	Mozaffarian D and Wu JH	(n-3) fatty acids and cardiovascular health: are effects of EPA and DHA shared or complementary?
22323767	J. Nutr.	2012	Deckelbaum RJ et al.	Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice.
22955512	J. Nutr.	2012	Zhao M et al.	Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.
23884386	J. Nutr.	2013	Muldoon MF et al.	Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults.
23616502	J. Nutr.	2013	Laird BD et al.	Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids.
23677863	J. Nutr.	2013	Ramkumar HL et al.	Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background.
23390192	J. Nutr.	2013	Phang M et al.	Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women.
23303872	J. Nutr.	2013	Depner CM et al.	Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.
23014495	J. Nutr.	2012	Liu Y et al.	Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge.
24005609	J. Nutr.	2013	Liu Y et al.	Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge.
24108131	J. Nutr.	2014	Bremer AA et al.	Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques.