Lycopene

Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.

References related to functions published in J. Nutr.

PMID	Journal	Published Date	Author	Title
9278568	J. Nutr.	1997	Johnson EJ et al.	Ingestion by men of a combined dose of beta-carotene and lycopene does not affect the absorption of beta-carotene but improves that of lycopene.
10356083	J. Nutr.	1999	Boileau AC et al.	Cis-lycopene is more bioavailable than trans-lycopene in vitro and in vivo in lymph-cannulated ferrets.
11880563	J. Nutr.	2002	Richelle M et al.	A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste.
11385062	J. Nutr.	2001	Boileau TW et al.	Testosterone and food restriction modulate hepatic lycopene isomer concentrations in male F344 rats.
12771341	J. Nutr.	2003	Wu K et al.	Variations in plasma lycopene and specific isomers over time in a cohort of U.S. men.
12949366	J. Nutr.	2003	Korytko PJ et al.	Pharmacokinetics and tissue distribution of orally administered lycopene in male dogs.
12672916	J. Nutr.	2003	Edwards AJ et al.	Consumption of watermelon juice increases plasma concentrations of lycopene and beta-carotene in humans.
12468619	J. Nutr.	2002	Livny O et al.	Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells.
12840203	J. Nutr.	2003	Sesso HD et al.	Dietary lycopene, tomato-based food products and cardiovascular disease in women.
10827218	J. Nutr.	2000	Boileau TW et al.	Tissue lycopene concentrations and isomer patterns are affected by androgen status and dietary lycopene concentration in male F344 rats.
10801917	J. Nutr.	2000	van het Hof KH et al.	Carotenoid bioavailability in humans from tomatoes processed in different ways determined from the carotenoid response in the triglyceride-rich lipoprotein fraction of plasma after a single consumption and in plasma after four days of consumption.
10801927	J. Nutr.	2000	Ferreira AL et al.	Tissue distribution of lycopene in ferrets and rats after lycopene supplementation.
10867042	J. Nutr.	2000	Watzl B et al.	Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women.
10720168	J. Nutr.	2000	Porrini M and Riso P	Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption.
14652370	J. Nutr.	2003	Zaripheh S et al.	[14C]-lycopene and [14C]-labeled polar products are differentially distributed in tissues of F344 rats prefed lycopene.
15284367	J. Nutr.	2004	Nishimukai M and Hara H	Enteral administration of soybean phosphatidylcholine enhances the lymphatic absorption of lycopene, but reduces that of alpha-tocopherol in rats.
14608044	J. Nutr.	2003	Obermüller-Jevic UC et al.	Lycopene inhibits the growth of normal human prostate epithelial cells in vitro.
20962153	J. Nutr.	2010	Ford NA et al.	Loss of carotene-9',10'-monooxygenase expression increases serum and tissue lycopene concentrations in lycopene-fed mice.
21593356	J. Nutr.	2011	Adkins B and Contractor N	Immune responses of female BALB/c and C57BL/6 neonatal mice to vaccination or intestinal infection are unaltered by exposure to breast milk lycopene.
18936233	J. Nutr.	2008	Chow CK	The relative efficacy of lycopene and beta-carotene in inhibiting experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice.
19297426	J. Nutr.	2009	Blanquet-Diot S et al.	Digestive stability of xanthophylls exceeds that of carotenes as studied in a dynamic in vitro gastrointestinal system.
19022959	J. Nutr.	2008	Lindshield BL et al.	Lycopene biodistribution is altered in 15,15'-carotenoid monooxygenase knockout mice.
18287363	J. Nutr.	2008	Huang CS et al.	Lycopene inhibits experimental metastasis of human hepatoma SK-Hep-1 cells in athymic nude mice.
15735099	J. Nutr.	2005	Nkondjock A et al.	Dietary intake of lycopene is associated with reduced pancreatic cancer risk.
15795436	J. Nutr.	2005	Reboul E et al.	Enrichment of tomato paste with 6% tomato peel increases lycopene and beta-carotene bioavailability in men.
15570058	J. Nutr.	2004	Campbell JK et al.	Tomato phytochemicals and prostate cancer risk.
16365067	J. Nutr.	2006	Liu C et al.	Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets.
16251620	J. Nutr.	2005	Sicilia T et al.	Novel lycopene metabolites are detectable in plasma of preruminant calves after lycopene supplementation.
15514294	J. Nutr.	2004	Heber D	Phytochemicals beyond antioxidation.
16046731	J. Nutr.	2005	Davis CD et al.	Executive summary report.
16046732	J. Nutr.	2005	Giovannucci E	Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature.
16046733	J. Nutr.	2005	Jenab M et al.	Variations in lycopene blood levels and tomato consumption across European countries based on the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
16046734	J. Nutr.	2005	Kristal AR and Schenk JM	Directions for future epidemiological research in lycopene and prostate cancer risk.
16046735	J. Nutr.	2005	Schwartz SJ	How can the metabolomic response to lycopene (exposures, durations, intracellular concentrations) in humans be adequately evaluated?
16046736	J. Nutr.	2005	Porrini M and Riso P	What are typical lycopene intakes?
16046737	J. Nutr.	2005	Erdman JW	How do nutritional and hormonal status modify the bioavailability, uptake, and distribution of different isomers of lycopene?
16046738	J. Nutr.	2005	Novotny JA	What can pharmacokinetic models tell us about the disposition of lycopene and the potential role of lycopene in cancer prevention?
16046739	J. Nutr.	2005	Siler U et al.	Lycopene effects on rat normal prostate and prostate tumor tissue.
16046740	J. Nutr.	2005	Wang XD	Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?
16046741	J. Nutr.	2005	Clinton SK	Tomatoes or lycopene: a role in prostate carcinogenesis?
16046742	J. Nutr.	2005	Trumbo PR	Are there adverse effects of lycopene exposure?
16046743	J. Nutr.	2005	van Breemen RB	How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?
16046745	J. Nutr.	2005	Bowen PE	Selection of surrogate endpoint biomarkers to evaluate the efficacy of lycopene/tomatoes for the prevention/progression of prostate cancer.
16046746	J. Nutr.	2005	Astley SB and Elliott RM	How strong is the evidence that lycopene supplementation can modify biomarkers of oxidative damage and DNA repair in human lymphocytes?
15671228	J. Nutr.	2005	Tang L et al.	Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice.
15867308	J. Nutr.	2005	Canene-Adams K et al.	The tomato as a functional food.
16484534	J. Nutr.	2006	Wang L et al.	The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women.
16549453	J. Nutr.	2006	Zaripheh S et al.	Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues.
16614418	J. Nutr.	2006	Limpens J et al.	Combined lycopene and vitamin E treatment suppresses the growth of PC-346C human prostate cancer cells in nude mice.
16702320	J. Nutr.	2006	Gajic M et al.	Apo-8'-lycopenal and apo-12'-lycopenal are metabolic products of lycopene in rat liver.
16140886	J. Nutr.	2005	Huang CS et al.	Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells.
18567756	J. Nutr.	2008	Veeramachaneni S et al.	High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats.
18641187	J. Nutr.	2008	Moussa M et al.	Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1.
18156403	J. Nutr.	2008	Schwarz S et al.	Lycopene inhibits disease progression in patients with benign prostate hyperplasia.
22259190	J. Nutr.	2012	Chung J et al.	Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice.
26581679	J. Nutr.	2016	Mumford SL et al.	Serum Antioxidants Are Associated with Serum Reproductive Hormones and Ovulation among Healthy Women.
26674763	J. Nutr.	2016	Moran NE et al.	Absorption and Distribution Kinetics of the 13C-Labeled Tomato Carotenoid Phytoene in Healthy Adults.
25644347	J. Nutr.	2015	Ip BC et al.	Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice.
25644336	J. Nutr.	2015	Zubair N et al.	Genetic variation predicts serum lycopene concentrations in a multiethnic population of postmenopausal women.