rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to functions published in Mol. Biol. Cell

PMID	Journal	Published Date	Author	Title
11451996	Mol. Biol. Cell	2001	Masur K et al.	High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells.
19339281	Mol. Biol. Cell	2009	Lima F et al.	Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism.
15342779	Mol. Biol. Cell	2004	Lladó A et al.	Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes.
15574884	Mol. Biol. Cell	2005	Wiedłocha A et al.	Phosphorylation-regulated nucleocytoplasmic trafficking of internalized fibroblast growth factor-1.
15917298	Mol. Biol. Cell	2005	Panaretakis T et al.	Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.