Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

References related to abnormalities published in Mol. Cancer Ther.


PMIDJournalPublished DateAuthorTitle
20124455Mol. Cancer Ther.2010Volate SR et al.Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.
15657349Mol. Cancer Ther.2005Mohammad RM et al.Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma.
15713891Mol. Cancer Ther.2005Xu L et al.(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer.
22188816Mol. Cancer Ther.2012Lian J et al.Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.