MAYTANSINE

MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.

References related to functions published in Mol. Cancer Ther.


PMIDJournalPublished DateAuthorTitle
20937594Mol. Cancer Ther.2010Lopus M et al.Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.
20937595Mol. Cancer Ther.2010Oroudjev E et al.Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.