Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

References related to functions published in Mol. Cancer Ther.

PMID	Journal	Published Date	Author	Title
21372225	Mol. Cancer Ther.	2011	Pang X et al.	(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.
20124455	Mol. Cancer Ther.	2010	Volate SR et al.	Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells.
16020667	Mol. Cancer Ther.	2005	Bauer JA et al.	Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.
15657349	Mol. Cancer Ther.	2005	Mohammad RM et al.	Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma.
15657350	Mol. Cancer Ther.	2005	Oliver CL et al.	(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.
15713891	Mol. Cancer Ther.	2005	Xu L et al.	(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer.
22188816	Mol. Cancer Ther.	2012	Lian J et al.	Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation.
23974697	Mol. Cancer Ther.	2013	Billard C	BH3 mimetics: status of the field and new developments.
18645028	Mol. Cancer Ther.	2008	Meng Y et al.	Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa.