Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

References related to genes published in Mol. Cancer Ther.

PMID	Journal	Published Date	Author	Title
21220503	Mol. Cancer Ther.	2011	Tsimberidou AM et al.	Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial.
19509263	Mol. Cancer Ther.	2009	Bekier ME et al.	Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit.
17308073	Mol. Cancer Ther.	2007	Failly M et al.	Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells.
15956256	Mol. Cancer Ther.	2005	Yang CP et al.	A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.
16985069	Mol. Cancer Ther.	2006	Bijman MN et al.	Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton.
14578462	Mol. Cancer Ther.	2003	Fuino L et al.	Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.