Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
14707271 | Mol. Cancer Ther. | 2003 | Honore S et al. | Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation. |
21220503 | Mol. Cancer Ther. | 2011 | Tsimberidou AM et al. | Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial. |
19509263 | Mol. Cancer Ther. | 2009 | Bekier ME et al. | Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit. |
17308073 | Mol. Cancer Ther. | 2007 | Failly M et al. | Combination of sublethal concentrations of epidermal growth factor receptor inhibitor and microtubule stabilizer induces apoptosis of glioblastoma cells. |
15956256 | Mol. Cancer Ther. | 2005 | Yang CP et al. | A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence. |
16985069 | Mol. Cancer Ther. | 2006 | Bijman MN et al. | Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton. |