Gossypol
Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.
References related to pathways published in Mol. Cancer Ther.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 16020667 | Mol. Cancer Ther. | 2005 | Bauer JA et al. | Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL. |
| 18645028 | Mol. Cancer Ther. | 2008 | Meng Y et al. | Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. |
| 20124455 | Mol. Cancer Ther. | 2010 | Volate SR et al. | Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells. |
| 21372225 | Mol. Cancer Ther. | 2011 | Pang X et al. | (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. |
| 22188816 | Mol. Cancer Ther. | 2012 | Lian J et al. | Sorafenib sensitizes (-)-gossypol-induced growth suppression in androgen-independent prostate cancer cells via Mcl-1 inhibition and Bak activation. |