trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to functions published in Mol. Cell. Biol.

PMID	Journal	Published Date	Author	Title
9774645	Mol. Cell. Biol.	1998	Madisen L et al.	The immunoglobulin heavy chain locus control region increases histone acetylation along linked c-myc genes.
10373540	Mol. Cell. Biol.	1999	Feng YQ et al.	Enhancer-dependent transcriptional oscillations in mouse erythroleukemia cells.
9632821	Mol. Cell. Biol.	1998	Jin S and Scotto KW	Transcriptional regulation of the MDR1 gene by histone acetyltransferase and deacetylase is mediated by NF-Y.
11585908	Mol. Cell. Biol.	2001	Abderrahmani A et al.	The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).
11533236	Mol. Cell. Biol.	2001	Amann JM et al.	ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.
12138181	Mol. Cell. Biol.	2002	Li J et al.	Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor.
11940673	Mol. Cell. Biol.	2002	Curradi M et al.	Molecular mechanisms of gene silencing mediated by DNA methylation.
12417725	Mol. Cell. Biol.	2002	Choy JS and Kron SJ	NuA4 subunit Yng2 function in intra-S-phase DNA damage response.
12697826	Mol. Cell. Biol.	2003	Mihaylova VT et al.	Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.
12724425	Mol. Cell. Biol.	2003	Jedrusik MA and Schulze E	Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing.
11113204	Mol. Cell. Biol.	2001	Feng YQ et al.	Position effects are influenced by the orientation of a transgene with respect to flanking chromatin.
15082762	Mol. Cell. Biol.	2004	Ahmed S et al.	A novel protein with similarities to Rb binding protein 2 compensates for loss of Chk1 function and affects histone modification in fission yeast.
15601862	Mol. Cell. Biol.	2005	Goeman F et al.	Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
17145766	Mol. Cell. Biol.	2007	Fang S et al.	Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.
16135786	Mol. Cell. Biol.	2005	Zhang Y et al.	Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription.