N-acetylsphingosine
N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
References related to functions published in Mol. Pharmacol.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 11179444 | Mol. Pharmacol. | 2001 | Chen CC et al. | Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells. |
| 11854443 | Mol. Pharmacol. | 2002 | Kondo T et al. | Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis. |
| 12606757 | Mol. Pharmacol. | 2003 | Cho YH et al. | Potentiation of lipopolysaccharide-inducible cyclooxygenase 2 expression by C2-ceramide via c-Jun N-terminal kinase-mediated activation of CCAAT/enhancer binding protein beta in macrophages. |
| 15155840 | Mol. Pharmacol. | 2004 | Park IN et al. | Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system. |