trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to abnormalities published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
11226290	Proc. Natl. Acad. Sci. U.S.A.	2001	Mishra N et al.	Trichostatin A reverses skewed expression of CD154, interleukin-10, and interferon-gamma gene and protein expression in lupus T cells.
23236151	Proc. Natl. Acad. Sci. U.S.A.	2012	McCullough SD et al.	Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.
23341636	Proc. Natl. Acad. Sci. U.S.A.	2013	Zhou G et al.	HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.