25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
References related to abnormalities published in Proc. Natl. Acad. Sci. U.S.A.
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 9789003 | Proc. Natl. Acad. Sci. U.S.A. | 1998 | Nohturfft A et al. | Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N. |
| 19805370 | Proc. Natl. Acad. Sci. U.S.A. | 2009 | Bauman DR et al. | 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. |
| 24994901 | Proc. Natl. Acad. Sci. U.S.A. | 2014 | Gold ES et al. | 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. |