Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

References related to functions published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
9843936	Proc. Natl. Acad. Sci. U.S.A.	1998	Sinha SC et al.	The antibody catalysis route to the total synthesis of epothilones.
12145320	Proc. Natl. Acad. Sci. U.S.A.	2002	Giannakakou P et al.	Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
10688884	Proc. Natl. Acad. Sci. U.S.A.	2000	Giannakakou P et al.	A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells.