Tetradecanoic acid

Tetradecanoic acid is a lipid of Fatty Acyls (FA) class. Tetradecanoic acid is associated with abnormalities such as Chronic lung disease, Infection, Spastic syndrome, Diabetes and Cardiovascular Diseases. The involved functions are known as Fatty acid biosynthetic process, Anabolism, lung alveolus development, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Homeostasis. Tetradecanoic acid often locates in Structure of parenchyma of lung, Blood, Head, Membrane and Cytoplasmic matrix. The associated genes with Tetradecanoic acid are SLC33A1 gene, SFTPA1 gene, P4HTM gene, Polypeptides and GPR132 gene. The related lipids are Fatty Acids, Nonesterified Fatty Acids, palmitoleic acid, Phosphatidylglycerols and Butanols.

References related to functions published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
9789019	Proc. Natl. Acad. Sci. U.S.A.	1998	Gaffney BJ and Marsh D	High-frequency, spin-label EPR of nonaxial lipid ordering and motion in cholesterol-containing membranes.
10618429	Proc. Natl. Acad. Sci. U.S.A.	2000	Wang JK et al.	The Nef protein of HIV-1 associates with rafts and primes T cells for activation.
10639166	Proc. Natl. Acad. Sci. U.S.A.	2000	Cho YS et al.	Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.
14699046	Proc. Natl. Acad. Sci. U.S.A.	2004	Tang C et al.	Entropic switch regulates myristate exposure in the HIV-1 matrix protein.
14707265	Proc. Natl. Acad. Sci. U.S.A.	2004	Resh MD	A myristoyl switch regulates membrane binding of HIV-1 Gag.
21670298	Proc. Natl. Acad. Sci. U.S.A.	2011	Alioua A et al.	Unconventional myristoylation of large-conductance Ca²⁺-activated K⁺ channel (Slo1) via serine/threonine residues regulates channel surface expression.
23401539	Proc. Natl. Acad. Sci. U.S.A.	2013	Vlach J and Saad JS	Trio engagement via plasma membrane phospholipids and the myristoyl moiety governs HIV-1 matrix binding to bilayers.
25964330	Proc. Natl. Acad. Sci. U.S.A.	2015	Tsai SY et al.	Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid.