rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to genes published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
9037024	Proc. Natl. Acad. Sci. U.S.A.	1997	Villani G and Attardi G	In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells.
10200266	Proc. Natl. Acad. Sci. U.S.A.	1999	Au HC et al.	The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria.
17360324	Proc. Natl. Acad. Sci. U.S.A.	2007	Liu Y et al.	A genomic screen for activators of the antioxidant response element.
17726098	Proc. Natl. Acad. Sci. U.S.A.	2007	Varma H et al.	Inhibitors of metabolism rescue cell death in Huntington's disease models.
18812510	Proc. Natl. Acad. Sci. U.S.A.	2008	Choi WS et al.	Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
9689052	Proc. Natl. Acad. Sci. U.S.A.	1998	Seo BB et al.	Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells.
25136123	Proc. Natl. Acad. Sci. U.S.A.	2014	Cleaver JE et al.	Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.