trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to locations published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
10618426	Proc. Natl. Acad. Sci. U.S.A.	2000	Chen WY and Townes TM	Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation.
15084747	Proc. Natl. Acad. Sci. U.S.A.	2004	Amor DJ et al.	Human centromere repositioning "in progress".
19052231	Proc. Natl. Acad. Sci. U.S.A.	2008	Slack MD et al.	Characterizing heterogeneous cellular responses to perturbations.
16176989	Proc. Natl. Acad. Sci. U.S.A.	2005	Xu CR et al.	Histone acetylation affects expression of cellular patterning genes in the Arabidopsis root epidermis.
23236151	Proc. Natl. Acad. Sci. U.S.A.	2012	McCullough SD et al.	Reelin is a target of polyglutamine expanded ataxin-7 in human spinocerebellar ataxia type 7 (SCA7) astrocytes.