Retinal

Retinal is a lipid of Prenol Lipids (PR) class. Retinal is associated with abnormalities such as Retinal Detachment, Uveitis, Endophthalmitis, Infection and LEBER CONGENITAL AMAUROSIS, TYPE II (disorder). The involved functions are known as Pigment, immunoreactivity, Infiltration, Energy Absorption and chromophore. Retinal often locates in Entire visual system, Autosome, Membrane, Basement membrane and Thoracic region (surface region of back). The associated genes with Retinal are isorhodopsin, RPE65 gene, RND1 gene, RPE gene and CASP8AP2 gene. The related lipids are Phosphatidylserines, Membrane Lipids, Fatty Acids, Liposomes and oxidized lipid. The related experimental models are Mouse Model, Knock-out and Genetically Engineered Mouse.

References related to locations published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
9391044	Proc. Natl. Acad. Sci. U.S.A.	1997	Han M et al.	The C9 methyl group of retinal interacts with glycine-121 in rhodopsin.
8962051	Proc. Natl. Acad. Sci. U.S.A.	1996	Roselli C et al.	Detection of a Yb3+ binding site in regenerated bacteriorhodopsin that is coordinated with the protein and phospholipid head groups.
8986774	Proc. Natl. Acad. Sci. U.S.A.	1996	Hasson KC et al.	The photoisomerization of retinal in bacteriorhodospin: experimental evidence for a three-state model.
9751768	Proc. Natl. Acad. Sci. U.S.A.	1998	Li T et al.	Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures.
10393943	Proc. Natl. Acad. Sci. U.S.A.	1999	Bieszke JA et al.	The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins.
10430852	Proc. Natl. Acad. Sci. U.S.A.	1999	Tanimura Y et al.	Femtochemistry.
11562477	Proc. Natl. Acad. Sci. U.S.A.	2001	Thompson CL et al.	Preservation of light signaling to the suprachiasmatic nucleus in vitamin A-deficient mice.
11504917	Proc. Natl. Acad. Sci. U.S.A.	2001	Royant A et al.	X-ray structure of sensory rhodopsin II at 2.1-A resolution.
11447258	Proc. Natl. Acad. Sci. U.S.A.	2001	Logunov SL et al.	The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies.
12034887	Proc. Natl. Acad. Sci. U.S.A.	2002	Dean DM et al.	All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light?
10869443	Proc. Natl. Acad. Sci. U.S.A.	2000	Van Hooser JP et al.	Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness.
15220479	Proc. Natl. Acad. Sci. U.S.A.	2004	Patel AB et al.	Coupling of retinal isomerization to the activation of rhodopsin.
21135214	Proc. Natl. Acad. Sci. U.S.A.	2010	Yamashita T et al.	Opn5 is a UV-sensitive bistable pigment that couples with Gi subtype of G protein.
21527723	Proc. Natl. Acad. Sci. U.S.A.	2011	Struts AV et al.	Solid-state 2H NMR relaxation illuminates functional dynamics of retinal cofactor in membrane activation of rhodopsin.
20616020	Proc. Natl. Acad. Sci. U.S.A.	2010	Raz-Prag D et al.	Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration.
18922772	Proc. Natl. Acad. Sci. U.S.A.	2008	Luecke H et al.	Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore.
15851682	Proc. Natl. Acad. Sci. U.S.A.	2005	Tsukamoto H et al.	A rhodopsin exhibiting binding ability to agonist all-trans-retinal.
16731629	Proc. Natl. Acad. Sci. U.S.A.	2006	Jin Y et al.	Bacteriorhodopsin (bR) as an electronic conduction medium: current transport through bR-containing monolayers.
22198838	Proc. Natl. Acad. Sci. U.S.A.	2012	Deupi X et al.	Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II.
23479626	Proc. Natl. Acad. Sci. U.S.A.	2013	Koyanagi M et al.	Homologs of vertebrate Opn3 potentially serve as a light sensor in nonphotoreceptive tissue.
27071115	Proc. Natl. Acad. Sci. U.S.A.	2016	Sparrow JR	Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics.
25825743	Proc. Natl. Acad. Sci. U.S.A.	2015	Kardamakis AA et al.	Tectal microcircuit generating visual selection commands on gaze-controlling neurons.