N-acetylsphingosine

N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.

References related to functions published in Proc. Natl. Acad. Sci. U.S.A.

PMID	Journal	Published Date	Author	Title
9520470	Proc. Natl. Acad. Sci. U.S.A.	1998	Galvan V and Roizman B	Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner.
10792026	Proc. Natl. Acad. Sci. U.S.A.	2000	De Nadai C et al.	Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
15466700	Proc. Natl. Acad. Sci. U.S.A.	2004	Suzuki E et al.	Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert.
15695581	Proc. Natl. Acad. Sci. U.S.A.	2005	Falluel-Morel A et al.	Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling.