Epothilone A

Epothilone a is a lipid of Polyketides (PK) class. Epothilone a is associated with abnormalities such as abnormal fragmented structure and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Polymerization, Mutation, Depolymerization, Musculoskeletal torsion, function and Negative Regulation of Microtubule Depolymerization. Epothilone a often locates in Microtubules, soluble, Nuclear Structure and Microtubule cytoskeleton. The associated genes with Epothilone A are C9 gene, SLC33A1 gene, KIF2C gene and HMHA1 gene.

References related to functions published in Science


PMIDJournalPublished DateAuthorTitle
10649995Science2000Tang L et al.Cloning and heterologous expression of the epothilone gene cluster.
15297674Science2004Nettles JH et al.The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
23287720Science2013Prota AE et al.Molecular mechanism of action of microtubule-stabilizing anticancer agents.