rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to functions published in Toxicol. Sci.

PMID	Journal	Published Date	Author	Title
12730627	Toxicol. Sci.	2003	Muscarella DE et al.	Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor.
10696782	Toxicol. Sci.	2000	Isenberg JS and Klaunig JE	Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells.
15319488	Toxicol. Sci.	2004	Sanderson JT et al.	Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.
15103049	Toxicol. Sci.	2004	Watson RE et al.	The value of DNA methylation analysis in basic, initial toxicity assessments.
17324951	Toxicol. Sci.	2007	Klintworth H et al.	Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis.
14976342	Toxicol. Sci.	2004	Newhouse K et al.	Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells.
17018646	Toxicol. Sci.	2007	Ramachandiran S et al.	Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation.
18480073	Toxicol. Sci.	2008	Sanchez M et al.	Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons.
23535362	Toxicol. Sci.	2013	Chorfa A et al.	Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
23997112	Toxicol. Sci.	2013	Garcia-Garcia A et al.	Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity.