Lycopene

Lycopene is a lipid of Prenol Lipids (PR) class. Lycopene is associated with abnormalities such as Consumption-archaic term for TB, Chronic disease, Dehydration, furuncle and Cardiovascular Diseases. The involved functions are known as Cell Differentiation process, Signal Transduction, Biochemical Pathway, Mutation and IGF-1 Signaling Pathway. Lycopene often locates in Body tissue, Hepatic, Blood, Adipose tissue and Structure of parenchyma of lung. The associated genes with Lycopene are EPB41L2 gene, VEGFB gene, P4HTM gene, FATE1 gene and SLC33A1 gene. The related lipids are Micelles, Liposomes, Total cholesterol, Steroids and apo-10'-lycopenoic acid. The related experimental models are Mouse Model, Knock-out, Cancer Model, Transgenic Model and Xenograft Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
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20699249	Carcinogenesis	2010	Palozza P et al.	Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
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20348305	Appl. Environ. Microbiol.	2010	Choi HS et al.	In silico identification of gene amplification targets for improvement of lycopene production.
20178989	J. Biol. Chem.	2010	Yu Q et al.	The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction.
17911344	Am. J. Physiol. Endocrinol. Metab.	2007	Napolitano M et al.	Effects of lycopene on the induction of foam cell formation by modified LDL.
17507623	Cancer Epidemiol. Biomarkers Prev.	2007	Peters U et al.	Serum lycopene, other carotenoids, and prostate cancer risk: a nested case-control study in the prostate, lung, colorectal, and ovarian cancer screening trial.
18283040	Carcinogenesis	2008	Liu X et al.	Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.
15781667	Cancer Res.	2005	Li H et al.	Manganese superoxide dismutase polymorphism, prediagnostic antioxidant status, and risk of clinical significant prostate cancer.
15894655	Cancer Epidemiol. Biomarkers Prev.	2005	Sesso HD et al.	Dietary and plasma lycopene and the risk of breast cancer.
16434593	Cancer Epidemiol. Biomarkers Prev.	2006	Kirsh VA et al.	A prospective study of lycopene and tomato product intake and risk of prostate cancer.
17213256	Cancer Res.	2007	Canene-Adams K et al.	Combinations of tomato and broccoli enhance antitumor activity in dunning r3327-h prostate adenocarcinomas.
18519700	Cancer Res.	2008	Mossine VV et al.	Interaction of tomato lycopene and ketosamine against rat prostate tumorigenesis.
22158914	Eur J Public Health	2012	Karppi J et al.	Low serum lycopene and β-carotene increase risk of acute myocardial infarction in men.
21430075	Cancer Prev Res (Phila)	2011	van Breemen RB et al.	Antioxidant effects of lycopene in African American men with prostate cancer or benign prostate hyperplasia: a randomized, controlled trial.
23076979	Eur J Cardiovasc Nurs	2013	Biddle M et al.	Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure.
24085778	Cancer Prev Res (Phila)	2013	Ip BC et al.	Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
25712483	J. Bacteriol.	2015	Yang Y et al.	Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
25602702	Arch. Biochem. Biophys.	2015	Sahin K et al.	Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model.
25592162	Arch. Biochem. Biophys.	2015	Stice CP et al.	Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models.
25469376	Adv Nutr	2014	Burton-Freeman B and Sesso HD	Whole food versus supplement: comparing the clinical evidence of tomato intake and lycopene supplementation on cardiovascular risk factors.
25385104	Antimicrob. Agents Chemother.	2015	Dai C et al.	Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.
25293877	Cancer Prev Res (Phila)	2014	Ip BC et al.	Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.