7-Ketocholesterol

7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.

References related to genes published in Others

PMID	Journal	Published Date	Author	Title
9837855	FASEB J.	1998	Lizard G et al.	Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production.
15364622	Cardiovasc. Res.	2004	Seye CI et al.	7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling.
18936140	Invest. Ophthalmol. Vis. Sci.	2009	Moreira EF et al.	7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation.
19834037	Invest. Ophthalmol. Vis. Sci.	2010	Gramajo AL et al.	Mitochondrial DNA damage induced by 7-ketocholesterol in human retinal pigment epithelial cells in vitro.
20554621	Invest. Ophthalmol. Vis. Sci.	2010	Larrayoz IM et al.	7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation.
17446432	Circ. Res.	2007	Wen Y and Leake DS	Low density lipoprotein undergoes oxidation within lysosomes in cells.
18245064	Cardiovasc. Res.	2008	Hans CP et al.	Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
17846428	Proc. Natl. Acad. Sci. U.S.A.	2007	Terasaka N et al.	High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1.
17122150	Invest. Ophthalmol. Vis. Sci.	2006	Luthra S et al.	Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells.
24028627	FEMS Yeast Res.	2013	Yue Q et al.	7-ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae.
21144857	Front Neuroendocrinol	2011	Wyrwoll CS et al.	11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.
20443782	Clin. Sci.	2010	Jarvie E et al.	Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring.
17709641	Circulation	2007	Myoishi M et al.	Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome.
25617738	Biochim. Biophys. Acta	2015	Lee JW et al.	Extra-hepatic metabolism of 7-ketocholesterol occurs by esterification to fatty acids via cPLA2α and SOAT1 followed by selective efflux to HDL.
25186795	Circ. Res.	2014	Rao X et al.	CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure.