Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
9437199	Arterioscler. Thromb. Vasc. Biol.	1997	Tsoukatos DC et al.	Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL.
9157962	Arterioscler. Thromb. Vasc. Biol.	1997	Frostegård J et al.	Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism.
9023292	J. Pharmacol. Exp. Ther.	1997	Riera M et al.	Neutrophils accentuate renal cold ischemia-reperfusion injury. Dose-dependent protective effect of a platelet-activating factor receptor antagonist.
11510782	Eur. Respir. J.	2001	Feldman C et al.	Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro.
11937571	J. Immunol.	2002	Silva AR et al.	Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein.
12356842	Invest. Ophthalmol. Vis. Sci.	2002	Beauchamp MH et al.	Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy.
10898747	Am. J. Physiol. Gastrointest. Liver Physiol.	2000	Parkman HP et al.	The contractile action of platelet-activating factor on gallbladder smooth muscle.
9760298	Circulation	1998	Kinn JW and Bache RJ	Effect of platelet activation on coronary collateral blood flow.
9412509	J. Neurosci.	1998	Bix GJ and Clark GD	Platelet-activating factor receptor stimulation disrupts neuronal migration In vitro.
15138217	Gut	2004	Yang Y et al.	Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis.
21257713	FASEB J.	2011	Garland RC et al.	Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury.
19773578	Am. J. Physiol. Endocrinol. Metab.	2009	Cheng L et al.	A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.
19603543	J. Clin. Invest.	2009	Camerer E et al.	Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
18339705	Am. J. Physiol. Gastrointest. Liver Physiol.	2008	Claud EC et al.	Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.
18441203	Am. J. Physiol. Heart Circ. Physiol.	2008	Leary PJ et al.	A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.
15456758	J. Biol. Chem.	2004	Bonin F et al.	Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit.
15728511	J. Immunol.	2005	Lin P et al.	Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP.
15994743	Eur. J. Endocrinol.	2005	Denizot Y et al.	Platelet-activating factor and human thyroid cancer.
16651419	Cancer Res.	2006	Heon Seo K et al.	Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation.
17182612	J. Biol. Chem.	2007	Shindou H et al.	A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.
22167755	Blood	2012	López-Sagaseta J et al.	sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove.