Lysophosphatidylcholine

Lysophosphatidylcholine is a lipid of Glycerophospholipids (GP) class. Lysophosphatidylcholine is associated with abnormalities such as Ischemia, Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Fatty Liver and Atherosclerosis. The involved functions are known as Inflammation, antagonists, Signal Transduction, Signal Pathways and Saturated. Lysophosphatidylcholine often locates in Body tissue, Head, integral to membrane, Membrane and Extracellular. The associated genes with Lysophosphatidylcholine are RHOA gene, Homologous Gene, GPR4 gene, GPR68 gene and TRPV2 gene. The related lipids are Nonesterified Fatty Acids, lysophosphatidylethanolamine, Lysophosphatidylcholines, Phosphatidylserines and 25-hydroxycholesterol. The related experimental models are Knock-out and Disease model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
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25307302	Clin. Biochem.	2015	Haynes CA and De Jesús VR	The stability of hexacosanoyl lysophosphatidylcholine in dried-blood spot quality control materials for X-linked adrenoleukodystrophy newborn screening.
24982116	Circulation	2014	Thiele JR et al.	Dissociation of pentameric to monomeric C-reactive protein localizes and aggravates inflammation: in vivo proof of a powerful proinflammatory mechanism and a new anti-inflammatory strategy.
24170693	Diabetes	2014	Zhu X et al.	Deletion of class A scavenger receptor deteriorates obesity-induced insulin resistance in adipose tissue.
23929934	Diabetes	2013	La Torre D et al.	Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes.
23514731	Diabetes Care	2013	Lehmann R et al.	Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver.
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21123073	Bioorg. Med. Chem.	2011	Choi J et al.	An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine.
20083230	Biochim. Biophys. Acta	2010	Sparkes BL et al.	Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemia/reperfusion.
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18356547	Stroke	2008	Mannheim D et al.	Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques.
17502572	Circulation	2007	Lavi S et al.	Local production of lipoprotein-associated phospholipase A2 and lysophosphatidylcholine in the coronary circulation: association with early coronary atherosclerosis and endothelial dysfunction in humans.
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15383458	Blood	2005	Yang LV et al.	Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.
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14662652	Hypertension	2004	Han JH et al.	Attenuation of lysophosphatidylcholine-induced suppression of ANP release from hypertrophied atria.
12925777	Mol. Biol. Cell	2003	Drecktrah D et al.	Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.
12734377	J. Immunol.	2003	Balboa MA et al.	Calcium-independent phospholipase A2 is required for lysozyme secretion in U937 promonocytes.
12719444	Hypertension	2003	Han JH et al.	Decreases in ANP secretion by lysophosphatidylcholine through protein kinase C.
12446479	Clin. Chem.	2002	Liebisch G et al.	High-throughput quantification of lysophosphatidylcholine by electrospray ionization tandem mass spectrometry.
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4328399	Blood	1971	Shohet SB et al.	Hereditary hemolytic anemia associated with abnormal membrane lipids: mechanism of accumulation of phosphatidyl choline.