Epothilone B
Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.
References related to abnormalities published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 12124345 | Cancer Res. | 2002 | Bröker LE et al. | Late activation of apoptotic pathways plays a negligible role in mediating the cytotoxic effects of discodermolide and epothilone B in non-small cell lung cancer cells. |
| 21220503 | Mol. Cancer Ther. | 2011 | Tsimberidou AM et al. | Effects of patupilone on the pharmacokinetics and pharmacodynamics of warfarin in patients with advanced malignancies: a phase I clinical trial. |
| 17289837 | J. Pharmacol. Exp. Ther. | 2007 | Lim Y et al. | Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins. |
| 18593821 | Mol. Pharmacol. | 2008 | Khawaja NR et al. | Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria. |
| 26883566 | Exp. Neurol. | 2016 | Pittman SK et al. | Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons. |