apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
11673497	J. Immunol.	2001	Shen J et al.	Phosphorylation by the protein kinase CK2 promotes calpain-mediated degradation of IkappaBalpha.
14563892	J. Antimicrob. Chemother.	2003	Koo H et al.	Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol.
14709621	Drug Metab. Dispos.	2004	Gradolatto A et al.	Metabolism of apigenin by rat liver phase I and phase ii enzymes and by isolated perfused rat liver.
21106916	Am. J. Clin. Nutr.	2011	Cassidy A et al.	Habitual intake of flavonoid subclasses and incident hypertension in adults.
21505181	Cancer Prev Res (Phila)	2011	Mafuvadze B et al.	Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats.
17982104	J. Immunol.	2007	Nicholas C et al.	Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.
15746177	FASEB J.	2005	Fang J et al.	Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.
15466493	Drug Metab. Dispos.	2005	Gradolatto A et al.	Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration.
15947208	Mol. Pharmacol.	2005	Liu LZ et al.	Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
17074806	Mol. Cell. Biol.	2007	Tong X et al.	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.
16873680	Diabetes	2006	Zang M et al.	Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.
16982614	J. Biol. Chem.	2006	Balasubramanian S et al.	Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311.
16782805	Mol. Pharmacol.	2006	Yoon MS et al.	Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant.
16581776	Mol. Cell. Biol.	2006	Li X et al.	NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.
23475986	Mol. Hum. Reprod.	2013	Lim R et al.	Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.
23113475	FEMS Microbiol. Lett.	2013	Dong J et al.	Apigenin alleviates the symptoms of Staphylococcus aureus pneumonia by inhibiting the production of alpha-hemolysin.
28396216	Toxicol. Appl. Pharmacol.	2017	Lecomte S et al.	Assessment of the potential activity of major dietary compounds as selective estrogen receptor modulators in two distinct cell models for proliferation and differentiation.
20693356	Plant Cell	2010	Ono E et al.	Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera).
18703119	Neuroscience	2008	Song J et al.	DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
25058688	Chem. Biol. Interact.	2014	Isoda H et al.	Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.
23782265	Biochem. J.	2013	Wiejak J et al.	Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
22732730	J Ethnopharmacol	2012	de Souza MR et al.	Pharmacological basis for use of Lychnophora trichocarpha in gouty arthritis: anti-hyperuricemic and anti-inflammatory effects of its extract, fraction and constituents.
22634381	Biochim. Biophys. Acta	2012	Caruana M et al.	Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro.
18793716	Cell. Signal.	2008	Harris SM et al.	The interferon-gamma-mediated inhibition of lipoprotein lipase gene transcription in macrophages involves casein kinase 2- and phosphoinositide-3-kinase-mediated regulation of transcription factors Sp1 and Sp3.
16781454	Free Radic. Biol. Med.	2006	Kachadourian R and Day BJ	Flavonoid-induced glutathione depletion: potential implications for cancer treatment.
14993215	J. Biol. Chem.	2004	Kuronuma K et al.	Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A.
26500281	Biosci. Rep.	2015	Seo HS et al.	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.
26475103	Appl. Environ. Microbiol.	2015	Xia F et al.	Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus.
25799526	J. Surg. Res.	2015	Mrazek AA et al.	Apigenin inhibits pancreatic stellate cell activity in pancreatitis.
24837156	Bioorg. Med. Chem.	2014	Chen H et al.	Design, synthesis, and characterization of novel apigenin analogues that suppress pancreatic stellate cell proliferation in vitro and associated pancreatic fibrosis in vivo.