FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
16443668	Drug Metab. Dispos.	2006	Kim SK et al.	The mitogen-activated protein kinase kinase (mek) inhibitor PD98059 elevates primary cultured rat hepatocyte glutathione levels independent of inhibiting mek.
21586682	Plant Cell	2011	Martin C et al.	How can research on plants contribute to promoting human health?
25498791	J. Allergy Clin. Immunol.	2015	Weng Z et al.	The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells.
21075959	Plant Physiol.	2011	Seo S et al.	Cyanide, a coproduct of plant hormone ethylene biosynthesis, contributes to the resistance of rice to blast fungus.
21075839	J. Pharmacol. Exp. Ther.	2011	Wootten D et al.	Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.
19324938	Diabetes	2009	Wang Y et al.	Inactivation of GSK-3beta by metallothionein prevents diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling.
14645680	Mol. Pharmacol.	2003	Wenzel U et al.	Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
11262417	J. Biol. Chem.	2001	Galietta LJ et al.	Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.