Prostaglandin E2

Prostaglandin E2 is a lipid of Fatty Acyls (FA) class. Prostaglandin e2 is associated with abnormalities such as Renal glomerular disease, Arthritis, Degenerative polyarthritis, Pancreatitis and Rheumatoid Arthritis. The involved functions are known as enzyme pathway, Atherogenesis, Anabolism, inhibitors and Oxidants. Prostaglandin e2 often locates in Tissue membrane, Blood, Extracellular, Membrane and Protoplasm. The associated genes with Prostaglandin E2 are PTGS2 gene, TP53 gene, TNFRSF5 gene, FASTK Gene and TNF gene. The related lipids are Lipopolysaccharides, Steroids, monooxyethylene trimethylolpropane tristearate, Fatty Acids, Unsaturated and Promega. The related experimental models are Arthritis, Adjuvant-Induced, Xenograft Model, Experimental Autoimmune Encephalomyelitis, Cancer Model and Knock-out.

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PMIDJournalPublished DateAuthorTitle
20032118Am. J. Physiol. Renal Physiol.2010Wang H et al.Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in mice.
12893632Am. J. Physiol. Gastrointest. Liver Physiol.2003Harada N et al.Contribution of capsaicin-sensitive sensory neurons to stress-induced increases in gastric tissue levels of prostaglandins in rats.
26906248J. Pharmacol. Sci.2016Sugita R et al.A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models.
19671757Mol. Cancer Ther.2009Koeberle A et al.Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1.
17483193Am. J. Physiol. Lung Cell Mol. Physiol.2007Larsen GL et al.Modulation of airway responses by prostaglandins in young and fully grown rabbits.
16926398Infect. Immun.2006Rydkina E et al.Infection of human endothelial cells with spotted Fever group rickettsiae stimulates cyclooxygenase 2 expression and release of vasoactive prostaglandins.
12384473Am. J. Physiol. Heart Circ. Physiol.2002Kodani E et al.Delta-opioid receptor-induced late preconditioning is mediated by cyclooxygenase-2 in conscious rabbits.
11135056Kidney Int.2001Peng H et al.Effect of indomethacin on peritoneal protein loss in a rabbit model of peritonitis.
25362177J. Immunol.2014Tsubosaka Y et al.A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation.
16699067J. Pharmacol. Exp. Ther.2006Hatazawa R et al.Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.
27664754Vascul. Pharmacol.2016Theiler A et al.The EP1/EP3 receptor agonist 17-pt-PGE2 acts as an EP4 receptor agonist on endothelial barrier function and in a model of LPS-induced pulmonary inflammation.
17363677Am. J. Physiol. Regul. Integr. Comp. Physiol.2007Bachteeva V et al.Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway.
25263346Prostaglandins Other Lipid Mediat.2014Kassem KM et al.PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
22977257J. Biol. Chem.2012Kocieda VP et al.Prostaglandin E2-induced IL-23p19 subunit is regulated by cAMP-responsive element-binding protein and C/AATT enhancer-binding protein β in bone marrow-derived dendritic cells.
22859831J. Leukoc. Biol.2012Serra-Pages M et al.E-prostanoid 2 receptors dampen mast cell degranulation via cAMP/PKA-mediated suppression of IgE-dependent signaling.
21896757Proc. Natl. Acad. Sci. U.S.A.2011Clasadonte J et al.Prostaglandin E2 release from astrocytes triggers gonadotropin-releasing hormone (GnRH) neuron firing via EP2 receptor activation.
21768374Proc. Natl. Acad. Sci. U.S.A.2011Olesen ET et al.Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus.
21715307Blood2011Van Elssen CH et al.Inflammation-restraining effects of prostaglandin E2 on natural killer-dendritic cell (NK-DC) interaction are imprinted during DC maturation.
21606476Thorax2011Buckley J et al.EP4 receptor as a new target for bronchodilator therapy.
19428786Neurochem. Int.2009Hutchinson AJ et al.Activation of EP2 prostanoid receptors in human glial cell lines stimulates the secretion of BDNF.
18981149J. Immunol.2008Sturm EM et al.Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors.
17557799Am. J. Physiol. Lung Cell Mol. Physiol.2007Thomas PE et al.PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling.
17053162Am. J. Physiol. Gastrointest. Liver Physiol.2007Moeser AJ et al.Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone.
16516814Prostaglandins Other Lipid Mediat.2006Matlhagela K and Taub MInvolvement of EP1 and EP2 receptors in the regulation of the Na,K-ATPase by prostaglandins in MDCK cells.
15292051Am. J. Physiol. Renal Physiol.2004Kopp UC et al.Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves.
12167591Am. J. Physiol. Renal Physiol.2002Imig JD et al.Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice.
11254729J. Immunol.2001Ikegami R et al.The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages.
9351373Arterioscler. Thromb. Vasc. Biol.1997Li SR et al.Modified LDL decreases the binding of prostaglandin E2, I2, and E1 onto monocytes in patients with peripheral vascular disease.
25450800Toxicon2015Zoccal KF et al.PPAR-γ activation by Tityus serrulatus venom regulates lipid body formation and lipid mediator production.
24820086Antimicrob. Agents Chemother.2014Fischer CD et al.Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.
12874281J. Biol. Chem.2003Demasi M et al.Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis.
24815497J Am Heart Assoc2014Beaudin AE et al.Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: implications for sleep apnea.
22802632Proc. Natl. Acad. Sci. U.S.A.2012Liu T et al.Prostaglandin E2 deficiency uncovers a dominant role for thromboxane A2 in house dust mite-induced allergic pulmonary inflammation.
19850905Arterioscler. Thromb. Vasc. Biol.2010Vila L et al.Heritability of thromboxane A2 and prostaglandin E2 biosynthetic machinery in a Spanish population.
15155179Am. J. Physiol. Gastrointest. Liver Physiol.2004Gookin JL et al.Nitric oxide synthase stimulates prostaglandin synthesis and barrier function in C. parvum-infected porcine ileum.
11884479J. Immunol.2002Hattar K et al.Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
11509629J. Immunol.2001Caughey GE et al.Roles of cyclooxygenase (COX)-1 and COX-2 in prostanoid production by human endothelial cells: selective up-regulation of prostacyclin synthesis by COX-2.
9473245Blood1998Pouliot M et al.Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes.
7039861Circ. Res.1982Kawasaki A and Needleman PContribution of thromboxane to renal resistance changes in the isolated perfused hydronephrotic rabbit kidney.
25820137J Am Heart Assoc2015Berry E et al.Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.
20083230Biochim. Biophys. Acta2010Sparkes BL et al.Intestinal lipid alterations occur prior to antibody-induced prostaglandin E2 production in a mouse model of ischemia/reperfusion.
21297111J. Biol. Chem.2011Frasch SC et al.Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity.
16467083Clin. Cancer Res.2006D'Orazi G et al.Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
26264225Reproduction2015Figueroa F et al.Role of macrophage secretions on rat polycystic ovary: its effect on apoptosis.
28571770Food Chem. Toxicol.2017Kim HG et al.Leptin induces CREB-dependent aromatase activation through COX-2 expression in breast cancer cells.
27659809Biochem. Pharmacol.2016Banerjee M et al.Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.
27697457Toxicology2016Su HH et al.Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism.
22974838Food Chem. Toxicol.2012Kang CH et al.Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation.
22693178Thorax2012Grace M et al.Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin.
22089456J. Rheumatol.2012Kapoor M et al.Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1.
21334316Chem. Biol. Interact.2011Yadav UC et al.Aldose reductase inhibition suppresses airway inflammation.
21251947Toxicology2011Liu J et al.Disrupting effects of bifenthrin on ovulatory gene expression and prostaglandin synthesis in rat ovarian granulosa cells.
20810888J. Neurosci.2010Koch H et al.Prostaglandin E2-induced synaptic plasticity in neocortical networks of organotypic slice cultures.
20171164Biochem. Biophys. Res. Commun.2010Kihara T et al.Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2.
19758985J. Biol. Chem.2009Wada M et al.Two pathways for cyclooxygenase-2 protein degradation in vivo.
19428335Biochem. Pharmacol.2009Megías J et al.Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes.
19397918Toxicol. Appl. Pharmacol.2009Zhang D et al.Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.
19273625J. Exp. Med.2009Boniface K et al.Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
18395713Exp. Cell Res.2008Kleiveland CR et al.Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms.
18378017Regul. Pept.2008Brzozowski T et al.Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide.
18187276Toxicol. Lett.2008Ahn EK et al.COX-2 expression and inflammatory effects by diesel exhaust particles in vitro and in vivo.
17242161J. Exp. Med.2007Gross S et al.Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors.
16868036J. Pharmacol. Exp. Ther.2006Brzozowski T et al.Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.
16644903J. Pharmacol. Exp. Ther.2006Claudino RF et al.Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema.
16489006Cancer Res.2006Hiraga T et al.Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
16325209Life Sci.2006Jiang X et al.COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism.
16293616J. Biol. Chem.2006Holla VR et al.Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer.
16251433J. Neurosci.2005Sang N et al.Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor.
15976003J. Am. Soc. Nephrol.2005Nüsing RM et al.Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome.
15930264Cancer Res.2005Chang SH et al.The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia.
15816358Exp. Toxicol. Pathol.2005Rincón-Sánchez AR et al.PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage.
15753380Cancer Res.2005Wang D et al.Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
15491851Nitric Oxide2004Jones CP et al.Prostaglandin E2 and dexamethasone regulate eosinophil differentiation and survival through a nitric oxide- and CD95-dependent pathway.
15311063J. Urol.2004Schröder A et al.Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice.
15236176Gastroenterology2004Darling RL et al.The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice.
15234114Neurochem. Int.2004Takadera T et al.Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons.
14514642Diabetes2003Kiritoshi S et al.Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy.
12370375J. Immunol.2002Madden KB et al.Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function.
12164941J. Invest. Dermatol.2002Kanda N and Watanabe SKetoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells.
12110441Bone2002Ahlen J et al.Characterization of the bone-resorptive effect of interleukin-11 in cultured mouse calvarial bones.
12077577J. Am. Acad. Dermatol.2002Neisius U et al.Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls.
11882577Hypertension2002Mendez M and LaPointe MCTrophic effects of the cyclooxygenase-2 product prostaglandin E(2) in cardiac myocytes.
11867761Proc. Natl. Acad. Sci. U.S.A.2002Zhu H et al.Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication.
11821123Toxicon2002Ribardo DA et al.Role of melittin-like region within phospholipase A(2)-activating protein in biological function.
11301049Biochem. Pharmacol.2001Shinomiya S et al.Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists.
11286988Biochem. Pharmacol.2001Nédélec E et al.Stimulation of cyclooxygenase-2-activity by nitric oxide-derived species in rat chondrocyte: lack of contribution to loss of cartilage anabolism.
11166334Neuropharmacology2001Averbeck B and Reeh PWInteractions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E(2) from isolated rat skin.
11060898Prostaglandins Other Lipid Mediat.2000Fain JN et al.Regulation of leptin release and lipolysis by PGE2 in rat adipose tissue.
10634944Biochim. Biophys. Acta2000Abramovitz M et al.The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
10432392Kidney Int.1999Jensen BL et al.Differential regulation of renal prostaglandin receptor mRNAs by dietary salt intake in the rat.
10231640J. Vasc. Surg.1999Miralles M et al.Indomethacin inhibits expansion of experimental aortic aneurysms via inhibition of the cox2 isoform of cyclooxygenase.
9743329J. Immunol.1998Wu CY et al.Prostaglandin E2 and dexamethasone inhibit IL-12 receptor expression and IL-12 responsiveness.
29046334EMBO J.2017Sabirov RZ et al.The organic anion transporter SLCO2A1 constitutes the core component of the Maxi-Cl channel.
28877931Mol. Pharmacol.2017Taylor EJA et al.Prostaglandin E2 Inhibits Histamine-Evoked Ca2+ Release in Human Aortic Smooth Muscle Cells through Hyperactive cAMP Signaling Junctions and Protein Kinase A.
28864467J. Pharmacol. Exp. Ther.2017Schippers M et al.Upregulation of Epac-1 in Hepatic Stellate Cells by Prostaglandin E2 in Liver Fibrosis Is Associated with Reduced Fibrogenesis.
28797762Vascul. Pharmacol.2017Zhang H et al.Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation.
28784844J. Immunol.2017Garth JM et al.IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection.
28780305Exp. Cell Res.2017Liu Y et al.Activated hepatic stellate cells directly induce pathogenic Th17 cells in chronic hepatitis B virus infection.
28760743FASEB J.2017Maier A et al.Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice.
28739154J. Am. Coll. Surg.2017Yip-Schneider MT et al.Prostaglandin E2: A Pancreatic Fluid Biomarker of Intraductal Papillary Mucinous Neoplasm Dysplasia.
28624453Biochem. Biophys. Res. Commun.2017Liang Y et al.Folic acid attenuates cobalt chloride-induced PGE2 production in HUVECs via the NO/HIF-1alpha/COX-2 pathway.
28483455Bioorg. Med. Chem.2017Umei K et al.Identification of novel 1,2,3,6-tetrahydropyridyl-substituted benzo[d]thiazoles: Lead generation and optimization toward potent and orally active EP1 receptor antagonists.
28438967J. Neurosci.2017Eskilsson A et al.Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E2 Synthesis in the Brain.
28341741J. Biol. Chem.2017Samuchiwal SK et al.Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway.
28300577Hum. Pathol.2017Zang S et al.PGE2 synthesis and signaling in malignant transformation and progression of human hepatocellular carcinoma.
28298525J. Immunol.2017Zasłona Z et al.The Induction of Pro-IL-1β by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production.
28288820Biochem. Pharmacol.2017Yang CM et al.Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblasts.
28283650
28263803Life Sci.2017Jin J et al.Prostaglandin E2 regulates renal function in C57/BL6 mouse with 5/6 nephrectomy.
28258202J. Immunol.2017Turcotte C et al.The Endocannabinoid Metabolite Prostaglandin E2 (PGE2)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE2 and EP Receptors.
28202625Cancer Discov2017Loo TM et al.Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
28193789Diabetes2017Neuman JC et al.Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function.
28174280Sci Signal2017Aoki T et al.Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms.
28137629Mol. Biochem. Parasitol.2017Kutyrev IA et al.Prostaglandins E2 and D2-regulators of host immunity in the model parasite Diphyllobothrium dendriticum: An immunocytochemical and biochemical study.
28065721Arch. Biochem. Biophys.2017Akasaka H et al.The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE2- and retaining PGE1-mediated signaling in live cells.
28062696J. Immunol.2017Hooper KM et al.Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1.
28040266Kidney Int.2017Frölich S et al.Angiotensin II-AT1-receptor signaling is necessary for cyclooxygenase-2-dependent postnatal nephron generation.
28025036Prostaglandins Other Lipid Mediat.2017Aslan İ et al.Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state.
27912969Phytochemistry2017Wu P et al.Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots.
27881647J. Virol.2017Alfajaro MM et al.Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production.
27864128Gastroenterology2017Kim HB et al.Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.
27856104J Pharm Biomed Anal2017Shui S et al.The investigation of anti-inflammatory activity of Yi Guanjian decoction by serum metabonomics approach.
27837675Neurobiol. Aging2017Maingret V et al.PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.
27834685Acupunct Med2016Zhang H et al.Antagonism of cannabinoid receptor 1 attenuates the anti-inflammatory effects of electroacupuncture in a rodent model of migraine.
27827823Blood2017Kawano Y et al.G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.
27806992FASEB J.2017Laan LC et al.The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells.
27503928Cancer Res.2016Alba-Castellón L et al.Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.
27765359Phytomedicine2016Hernández M et al.Cardioprotective actions of curcumin on the pathogenic NFAT/COX-2/prostaglandin E2 pathway induced during Trypanosoma cruzi infection.
27687956Pharmacol. Res.2016Huang CW et al.A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo.
27667770Pharmacol. Res.2016Villa V et al.Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.
27597642Pharmacol. Res.2016Joshi V et al.Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2.
27745800J Chin Med Assoc2017Kansu-Celik H et al.Prostaglandin E2 induction of labor and cervical ripening for term isolated oligohydramnios in pregnant women with Bishop score ≤ 5.
27717845Life Sci.2016Vieira AS et al.Janus kinase 2 activation participates in prostaglandin E2-induced hyperalgesia.
27616330Biochim. Biophys. Acta2016Filipenko I et al.Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation.
27597418Eur J Med Chem2016Ramanan M et al.Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.
27572469J. Pharmacol. Exp. Ther.2016Rezq S and Abdel-Rahman AARostral Ventrolateral Medulla EP3 Receptor Mediates the Sympathoexcitatory and Pressor Effects of Prostaglandin E2 in Conscious Rats.
27569861Chem. Biol. Interact.2016Kim KN et al.5-Bromo-2-hydroxy-4-methyl-benzaldehyde inhibited LPS-induced production of pro-inflammatory mediators through the inactivation of ERK, p38, and NF-κB pathways in RAW 264.7 macrophages.
27524299J Chromatogr A2016Shin JS et al.Direct analysis of prostaglandin-E2 and -D2 produced in an inflammatory cell reaction and its application for activity screening and potency evaluation using turbulent flow chromatography liquid chromatography-high resolution mass spectrometry.
27515217Med. Hypotheses2016Chen Y et al.Prostaglandin E2 and Connexin 43 crosstalk in the osteogenesis induced by extracorporeal shockwave.
27502370Circ Heart Fail2016Gu X et al.Prostaglandin E2 Reduces Cardiac Contractility via EP3 Receptor.
27498238Brain Res.2016Borham LE et al.The effect of some immunomodulatory and anti-inflammatory drugs on Li-pilocarpine-induced epileptic disorders in Wistar rats.
27481248Infect. Immun.2016Bhattacharjee A et al.Leishmania donovani-Induced Prostaglandin E2 Generation Is Critically Dependent on Host Toll-Like Receptor 2-Cytosolic Phospholipase A2 Signaling.
27473979Res. Vet. Sci.2016Maślanka T et al.Prostaglandin E2 exerts the proapoptotic and antiproliferative effects on bovine NK cells.
27450019Toxicol. Appl. Pharmacol.2016Akram M et al.A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target.
27424146Cytotherapy2016Hansen M et al.Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21.
27374223Cancer Cell2016Hou W et al.Oncolytic Virus-Mediated Targeting of PGE2 in the Tumor Alters the Immune Status and Sensitizes Established and Resistant Tumors to Immunotherapy.
27262506Exp. Cell Res.2016Hassan L et al.Resistance to ursolic acid-induced apoptosis through involvement of melanogenesis and COX-2/PGE2 pathways in human M4Beu melanoma cancer cells.
27260940Vascul. Pharmacol.2016Kraemer MP et al.Regulation of arterial reactivity by concurrent signaling through the E-prostanoid receptor 3 and angiotensin receptor 1.
27234891Bioorg. Med. Chem.2016Vasilakaki S et al.Inhibitors of secreted phospholipase A2 suppress the release of PGE2 in renal mesangial cells.
27217589J. Pharmacol. Exp. Ther.2016Woodward DF et al.Prostaglandin E2-Glyceryl Ester: In Vivo Evidence for a Distinct Pharmacological Identity from Intraocular Pressure Studies.
27181513Neurosci. Lett.2016Nassar A et al.Psychotropic drugs attenuate lipopolysaccharide-induced hypothermia by altering hypothalamic levels of inflammatory mediators in rats.
27177970Arch. Biochem. Biophys.2016Akasaka H and Ruan KHIdentification of the two-phase mechanism of arachidonic acid regulating inflammatory prostaglandin E2 biosynthesis by targeting COX-2 and mPGES-1.
27131287Environ. Toxicol. Pharmacol.2016Dilshara MG et al.Morin downregulates nitric oxide and prostaglandin E2 production in LPS-stimulated BV2 microglial cells by suppressing NF-κB activity and activating HO-1 induction.
27105159Atherosclerosis2016Santilli F et al.The Coxib case: Are EP receptors really guilty?
27038655Biochem. Pharmacol.2016Chiappini F et al.Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells.
27033904Res. Vet. Sci.2016Przybysz J et al.The influence of prostaglandin E2 on the production of IFN-γ by bovine CD4(+), CD8(+) and WC1(+) T cells.
27021874Toxicol In Vitro2016Paudel KR et al.Cepharanthine inhibits in vitro VSMC proliferation and migration and vascular inflammatory responses mediated by RAW264.7.
27012893Int. J. Biol. Macromol.2016Gupta A and Aparoy PInsights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design.
27001836Proc. Natl. Acad. Sci. U.S.A.2016Hangai S et al.PGE2 induced in and released by dying cells functions as an inhibitory DAMP.
26989254Science2016Duffin R et al.Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.
26970310Biochem. Biophys. Res. Commun.2016Wang H et al.Metastasis-associated protein 1 (MTA1) signaling in rheumatoid synovium: Regulation of inflammatory response and cytokine-mediated production of prostaglandin E2 (PGE2).
26932930FASEB J.2016Chan PC et al.Importance of adipocyte cyclooxygenase-2 and prostaglandin E2-prostaglandin E receptor 3 signaling in the development of obesity-induced adipose tissue inflammation and insulin resistance.
26926362Prostaglandins Leukot. Essent. Fatty Acids2016Bonanno A et al.Prostaglandin E₂ possesses different potencies in inducing Vascular Endothelial Growth Factor and Interleukin-8 production in COPD human lung fibroblasts.
26920260Food Chem2016Kim YS et al.Anti-inflammatory action of high molecular weight Mytilus edulis hydrolysates fraction in LPS-induced RAW264.7 macrophage via NF-κB and MAPK pathways.
26912395J. Lipid Res.2016Hu X et al.Major role of adipocyte prostaglandin E2 in lipolysis-induced macrophage recruitment.
26888865Cancer Prev Res (Phila)2016Maeda Y et al.Myeloid Differentiation Factor 88 Signaling in Bone Marrow-Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment.
26868972Neuroscience2016Liu H and Duan SRProstaglandin E2-mediated upregulation of neuroexcitation and persistent tetrodotoxin-resistant Na(+) currents in Ah-type trigeminal ganglion neurons isolated from adult female rats.
26850138Exp. Cell Res.2016Kasai T et al.Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.
26835987Int. J. Biol. Macromol.2016Wang Q et al.A pure polysaccharide from Ephedra sinica treating on arthritis and inhibiting cytokines expression.
26826430Mol. Cell. Endocrinol.2016Liu C et al.Inhibition of lysyl oxidase by prostaglandin E2 via EP2/EP4 receptors in human amnion fibroblasts: Implications for parturition.
26817629Endocr. Relat. Cancer2016Swami S et al.Vitamin D mitigates the adverse effects of obesity on breast cancer in mice.
26795547Virus Res.2016Procario MC et al.Prostaglandin E2 production during neonatal respiratory infection with mouse adenovirus type 1.
26779946Fitoterapia2016Zhang L et al.Anti-inflammatory cyclopentene derivatives from the inner bark of Tabebuia avellanedae.
26744410Clin. Sci.2016Evans IC et al.Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis.
26692285Prostaglandins Other Lipid Mediat.2016Gose T et al.Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE3.
26659713Br J Ophthalmol2016Wang L et al.Anterior chamber interleukin 1β, interleukin 6 and prostaglandin E2 in patients undergoing femtosecond laser-assisted cataract surgery.
26658718Biochim. Biophys. Acta2016Fernández-Martínez AB et al.Intracellular prostaglandin E2 mediates cisplatin-induced proximal tubular cell death.
26658365Arch. Oral Biol.2016Gümüş P et al.Evaluation of the gingival inflammation in pregnancy and postpartum via 25-hydroxy-vitamin D3, prostaglandin E2 and TNF-α levels in saliva.
26644349FASEB J.2016Naini SM et al.Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity.
26608124Neuroscience2016Simm B et al.Effects of prostaglandin E2 on cells cultured from the rat organum vasculosum laminae terminalis and median preoptic nucleus.
26596719J Biomech2015Liu C et al.Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage.
26585956Blood2016Aghourian MN et al.Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.
26549149Vet. Immunol. Immunopathol.2015Tsuchiya H et al.Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
26547885Vet. Immunol. Immunopathol.2015Wyns H et al.Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation.
26546575J. Pharmacol. Exp. Ther.2016Mistretta FA et al.DFL23448, A Novel Transient Receptor Potential Melastin 8-Selective Ion Channel Antagonist, Modifies Bladder Function and Reduces Bladder Overactivity in Awake Rats.
26543101Arterioscler. Thromb. Vasc. Biol.2016Gao C et al.Microsomal Prostaglandin E Synthase-1-Derived PGE2 Inhibits Vascular Smooth Muscle Cell Calcification.
26522832Toxicol. Appl. Pharmacol.2015Goswami SK et al.Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model.
26510582Int. J. Biochem. Cell Biol.2015Mateu A et al.Cross-talk between TLR4 and PPARγ pathways in the arachidonic acid-induced inflammatory response in pancreatic acini.
26474801Biochem. Pharmacol.2015Shimada H et al.OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion.
26463849Prostaglandins Other Lipid Mediat.2015Mawhin MA et al.The receptor EP3 to PGE2: A rational target to prevent atherothrombosis without inducing bleeding.
26453752J. Immunol.2015Chung ES et al.Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease.
26434370J. Pediatr.2015Siljehav V et al.Prostaglandin E2 Mediates Cardiorespiratory Disturbances during Infection in Neonates.
26403276Biochim. Biophys. Acta2015Blirando K et al.The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation.
26390819Life Sci.2015Kurokawa T et al.Underlying mechanisms of urine storage dysfunction in rats with salt-loading hypertension.
26342029J. Immunol.2015Liu T et al.Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.
26319242J. Am. Soc. Nephrol.2016Nasrallah R et al.PGE2, Kidney Disease, and Cardiovascular Risk: Beyond Hypertension and Diabetes.
26256195Carbohydr Polym2015Chen Q et al.Xanthan gum protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro.
26255103J. Allergy Clin. Immunol.2016Kondeti V et al.Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.
26253311Med. Hypotheses2015Foster J et al.Is prostaglandin E2 (PGE2) involved in the thermogenic response to environmental cooling in healthy humans?
26210574Cytotherapy2015Stucky EC et al.Alginate micro-encapsulation of mesenchymal stromal cells enhances modulation of the neuro-inflammatory response.
26209241Prostaglandins Other Lipid Mediat.2015Mastalerz L et al.Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics.
26188583J. Dairy Sci.2015Deng Q et al.Intravaginally administered lactic acid bacteria expedited uterine involution and modulated hormonal profiles of transition dairy cows.
26157044J. Pharmacol. Exp. Ther.2015Wang D et al.Activation of Mas Oncogene-Related G Protein-Coupled Receptors Inhibits Neurochemical Alterations in the Spinal Dorsal Horn and Dorsal Root Ganglia Associated with Inflammatory Pain in Rats.
26150361Prostaglandins Other Lipid Mediat.2015Sasaki Y et al.Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis.
26143011Neuroscience2015Dutra RC et al.The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.
26142955Exp. Eye Res.2015Kudryavtseva O et al.Prostaglandin induced changes in the tone of porcine retinal arterioles in vitro involve other factors than calcium activity in perivascular cells.
26123522Biochem. Pharmacol.2015Koeberle A and Werz OPerspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.
26119525Toxicol In Vitro2015Gutowska I et al.Fluoride as a factor initiating and potentiating inflammation in THP1 differentiated monocytes/macrophages.
26100911Proc. Natl. Acad. Sci. U.S.A.2015Gao M et al.Disruption of prostaglandin E2 receptor EP4 impairs urinary concentration via decreasing aquaporin 2 in renal collecting ducts.
26079093Exp. Physiol.2015Ali SS et al.Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats.
26077962Thromb. Res.2015Friedman EA et al.Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease.
26063630Naunyn Schmiedebergs Arch. Pharmacol.2015Granato C et al.Prostaglandin E2 excitatory effects on rat urinary bladder: a comparison between the β-adrenoceptor modulation of non-voiding activity in vivo and micro-contractile activity in vitro.
26026498Toxicol In Vitro2015Park HR and Loch-Caruso RProtective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro.
26001880Prostaglandins Other Lipid Mediat.2015Le Maître E et al.Impaired vagus-mediated immunosuppression in microsomal prostaglandin E synthase-1 deficient mice.
25962903J. Allergy Clin. Immunol.2015Säfholm J et al.Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor.
25916550Cell Res.2015Li P et al.Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
25911511Gastroenterology2015Cenac N et al.Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome.
25872797Int. J. Mol. Med.2015Ha C et al.Hydrogen sulfide attenuates IL-1β-induced inflammatory signaling and dysfunction of osteoarthritic chondrocytes.
25812673J. Matern. Fetal. Neonatal. Med.2016Singh N et al.Does aberrant expression of cyclooxygenase-2 and prostaglandin-E2 receptor genes lead to abortion in Chlamydia trachomatis-infected women.
25771128Toxicol. Appl. Pharmacol.2015Wrobel MH et al.The adverse effects of aldrin and dieldrin on both myometrial contractions and the secretory functions of bovine ovaries and uterus in vitro.
25753843Immunopharmacol Immunotoxicol2015El Morsy EM et al.Attenuating effects of coenzyme Q10 and amlodipine in ulcerative colitis model in rats.
25630423Dig. Dis. Sci.2015Baird AC et al.Prostaglandin E₂ and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function.
25501336Int J Mol Sci2014Lin CY et al.Pheophytin a inhibits inflammation via suppression of LPS-induced nitric oxide synthase-2, prostaglandin E2, and interleukin-1β of macrophages.
25482406Hepatology2015Choe WH and Baik SKProstaglandin E2 -mediated immunosuppression and the role of albumin as its modulator.
25465287J. Neuroimmunol.2014Damm J et al.Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: brain inflammatory responses are related to peripheral IL-6 rather than interferons.
25461458Pharmacol. Res.2014Martinez-Cutillas M et al.EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: pharmacological characterization.
25460828Prostaglandins Other Lipid Mediat.Montrose DC et al.The role of PGE2 in intestinal inflammation and tumorigenesis.
25460827Prostaglandins Other Lipid Mediat.Li YJ et al.Prostaglandin E2 switches from a stimulator to an inhibitor of cell migration after epithelial-to-mesenchymal transition.
25458900Prostaglandins Leukot. Essent. Fatty Acids2014Piao YL et al.Wound healing effects of new 15-hydroxyprostaglandin dehydrogenase inhibitors.
25454976J. Surg. Res.2015Hu Z et al.Ursolic acid improves survival and attenuates lung injury in septic rats induced by cecal ligation and puncture.
25454762Nutr Res2014Jayasooriya RG et al.Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway.
25451282Neuroscience2015Miranda J et al.Effect of pain chronification and chronic pain on an endogenous pain modulation circuit in rats.
25446121Biochem. Biophys. Res. Commun.2015Kim S et al.Prostaglandin potentiates 5-HT responses in stomach and ileum innervating visceral afferent sensory neurons.
25358789Stem Cell Reports2014Rodriguez R et al.Human bone marrow stromal cells lose immunosuppressive and anti-inflammatory properties upon oncogenic transformation.
25310697PLoS ONE2014Peacock O et al.Inflammation and MiR-21 pathways functionally interact to downregulate PDCD4 in colorectal cancer.
25241065Neuroscience2014Grace PM et al.Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae.
25213103J. Pharm. Pharmacol.2015Araujo e Silva AC et al.Role of gastric acid inhibition, prostaglandins and endogenous-free thiol groups on the gastroprotective effect of a proteolytic fraction from Vasconcellea cundinamarcensis latex.
25186613Cancer Immunol. Immunother.2014Hattar K et al.Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis.
25184246Am J Sports Med2014Dolkart O et al.Statins enhance rotator cuff healing by stimulating the COX2/PGE2/EP4 pathway: an in vivo and in vitro study.
25168428Toxicol. Appl. Pharmacol.2014Jin SH et al.Keratinocyte-derived IL-24 plays a role in the positive feedback regulation of epidermal inflammation in response to environmental and endogenous toxic stressors.
25122761J. Biol. Chem.2014Shridas P et al.Group X secretory phospholipase A2 regulates insulin secretion through a cyclooxygenase-2-dependent mechanism.
25118941Mol Med Rep2014Bao JP et al.Visceral adipose tissue-derived serine protease inhibitor inhibits interleukin-1β-induced catabolic and inflammatory responses in murine chondrocytes.
25110109Mol Med Rep2014Liu N et al.Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
25046208Am. J. Reprod. Immunol.2015Lappas MCellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators.
24992627
24980222Am J Rhinol AllergyShin JM et al.Inhibitory effect of prostaglandin E(2) on the migration of nasal fibroblasts.
24948542J. Surg. Res.2014Zheng Q et al.Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
24894428Clin. Exp. Immunol.2014Hodge G et al.Lung cancer is associated with decreased expression of perforin, granzyme B and interferon (IFN)-γ by infiltrating lung tissue T cells, natural killer (NK) T-like and NK cells.
24861422J. Neurosci. Methods2014Gruen M et al.Use of dynamic weight bearing as a novel end-point for the assessment of abdominal pain in the LPS-induced peritonitis model in the rat.
24859013Cell. Immunol.2014Dilshara MG et al.Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells.
24824317BJOG2015Grobman WAIs it time for outpatient cervical ripening with prostaglandins?
24810489Angle Orthod2015Jin Y et al.Functional role of mechanosensitive ion channel Piezo1 in human periodontal ligament cells.
24807327Obstet Gynecol2014Edwards RK et al.Foley catheter compared with the controlled-release dinoprostone insert: a randomized controlled trial.
24792209Osteoarthr. Cartil.2014Yoshioka K et al.Pharmacological effects of novel cross-linked hyaluronate, Gel-200, in experimental animal models of osteoarthritis and human cell lines.
24768319Mol. Immunol.2015Torres R et al.The PGE2-EP2-mast cell axis: an antiasthma mechanism.
24752596J Anesth2014Kim JD et al.Effect of propofol on prostaglandin E2 production and prostaglandin synthase-2 and cyclooxygenase-2 expressions in amniotic membrane cells.
24726877Immunity2014Coulombe F et al.Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.
24636062Chin J Nat Med2014Kim JH et al.Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi.
24621265Aging Cell2014Wang P et al.Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells.
24559044J Nanobiotechnology2014Inui S et al.Reduction of conspicuous facial pores by topical fullerene: possible role in the suppression of PGE2 production in the skin.
24439901Cell Host Microbe2014Kim YG et al.Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.
24433989J Gynecol Obstet Biol Reprod (Paris)2014Gaudineau A and Vayssière C[Cervical ripening with misoprostol with a live fetus].
24383868Can. J. Physiol. Pharmacol.2014Talukder JR et al.Lactoferrin ameliorates prostaglandin E2-mediated inhibition of Na+ -glucose cotransport in enterocytes.
24355293Life Sci.2014Malvar Ddo C et al.Antinociceptive, anti-inflammatory and antipyretic effects of 1.5-diphenyl-1H-Pyrazole-3-carbohydrazide, a new heterocyclic pyrazole derivative.
24338998Mol Nutr Food Res2014Kim MS et al.Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions.
24333565Exp. Neurol.2014Kaushik MK et al.Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.
24200844Life Sci.2013Mendizábal Y et al.Vasoactive effects of prostaglandins from the perivascular fat of mesenteric resistance arteries in WKY and SHROB rats.
24157494J Perinatol2014Faucett AM et al.Oral misoprostol versus vaginal dinoprostone for labor induction in nulliparous women at term.
24127286Mol. Carcinog.2015Woo SM et al.Silymarin suppresses the PGE2 -induced cell migration through inhibition of EP2 activation; G protein-dependent PKA-CREB and G protein-independent Src-STAT3 signal pathways.
24118119J. Clin. Periodontol.2013Sánchez GA et al.Salivary IL-1β and PGE2 as biomarkers of periodontal status, before and after periodontal treatment.
24074742Nutr Res2013Zhang D et al.Modified apple polysaccharides suppress the migration and invasion of colorectal cancer cells induced by lipopolysaccharide.
24072780FASEB J.2014Okunishi K et al.Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions.
24071564Cell. Immunol.Ying X et al.Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells.
24060896Hypertension2013Ren Y et al.Prostaglandin E2 mediates connecting tubule glomerular feedback.
24055573Prostaglandins Leukot. Essent. Fatty Acids2013Frolov A et al.Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice.
24007274Stem Cells Dev.2014Barbeau DJ et al.Early growth response-2 signaling mediates immunomodulatory effects of human multipotential stromal cells.
23918232Chin J Integr Med2013Zhu XX et al.Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.
23895161Am. J. Chin. Med.2013Koppula S et al.Carpesium macrocephalum attenuates lipopolysaccharide-induced inflammation in macrophages by regulating the NF-κB/IκB-α, Akt, and STAT signaling pathways.
23859562Langmuir2013Majumder J et al.β-Amino acid and amino-alcohol conjugation of a nonsteroidal anti-inflammatory drug (NSAID) imparts hydrogelation displaying remarkable biostability, biocompatibility, and anti-inflammatory properties.
23796953Trends Pharmacol. Sci.2013Jiang J and Dingledine RProstaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection.
23766471Invest. Ophthalmol. Vis. Sci.2013Wang JW et al.Differential effects of prostaglandin E2-sensitive receptors on contractility of human ocular cells that regulate conventional outflow.
23686005Environ. Toxicol. Pharmacol.2013Dilshara MG et al.Downregulation of pro-inflammatory mediators by a water extract of Schisandra chinensis (Turcz.) Baill fruit in lipopolysaccharide-stimulated RAW 264.7 macrophage cells.
23682071Cancer Prev Res (Phila)2013Mikulec CD et al.The chemopreventive efficacies of nonsteroidal anti-inflammatory drugs: the relationship of short-term biomarkers to long-term skin tumor outcome.
23665401Toxicol In Vitro2013McDermott C et al.Alterations in acetylcholine, PGE2 and IL6 release from urothelial cells following treatment with pyocyanin and lipopolysaccharide.
23630358J. Immunol.2013Domingo-Gonzalez R et al.Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant.
23622726J. Surg. Res.2013Wu BG et al.High-lipid enteral nutrition could partially mitigate inflammation but not lung injury in hemorrhagic shock rats.
23619528Pharmacol. Res.2013Hussain M et al.Multilevel pharmacological manipulation of adenosine-prostaglandin E₂/cAMP nexus in the tumor microenvironment: a 'two hit' therapeutic opportunity.
23586622J. Periodont. Res.2013Mizutani H et al.Lipopolysaccharide of Aggregatibacter actinomycetemcomitans up-regulates inflammatory cytokines, prostaglandin E2 synthesis and osteoclast formation in interleukin-1 receptor antagonist-deficient mice.
23579073Biochim. Biophys. Acta2013Sonne SR et al.Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.
23568971J. Physiol. Pharmacol.2013Bogacka I et al.In vitro effect of peroxisome proliferator activated receptor (PPAR) ligands on prostaglandin E2 synthesis and secretion by porcine endometrium during the estrous cycle and early pregnancy.
23507189Eur J Med Chem2013Olajide OA et al.Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition.
23485729Mol. Cell. Endocrinol.2013Stratakis CAcAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse.
23439561Mol. Pharmacol.2013Zhou X et al.NADPH oxidase NOX5-S and nuclear factor κB1 mediate acid-induced microsomal prostaglandin E synthase-1 expression in Barrett's esophageal adenocarcinoma cells.
23395999Toxicol. Appl. Pharmacol.2013Kakita H et al.Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production.
23343963Digestion2013Tsujii MCyclooxygenase, cancer stem cells and DNA methylation play important roles in colorectal carcinogenesis.
23298698Pharmacol. Res.2013Torres R et al.Locally administered prostaglandin E2 prevents aeroallergen-induced airway sensitization in mice through immunomodulatory mechanisms.
23262148Prostaglandins Other Lipid Mediat.Srivastava T et al.Fluid flow shear stress upregulates prostanoid receptor EP2 but not EP4 in murine podocytes.
23237743Prostaglandins Other Lipid Mediat.2013Xu J et al.Additive effect of prostaglandin E2 and adenosine in mouse experimental autoimmune encephalomyelitis.
23235695Cell. Physiol. Biochem.2012Ji YR et al.Mesenchymal stem cells support proliferation and terminal differentiation of B cells.
23230009Plant Foods Hum Nutr2012Bony E et al.Chemical composition and anti-inflammatory properties of the unsaponifiable fraction from awara (Astrocaryum vulgare M.) pulp oil in activated J774 macrophages and in a mice model of endotoxic shock.
23201570Prostaglandins Other Lipid Mediat.Li H et al.Regulation of T helper cell subsets by cyclooxygenases and their metabolites.
23149922Cancer Res.2013Ho MY et al.MIG-7 controls COX-2/PGE2-mediated lung cancer metastasis.
23138406Spine2013Wang IC et al.Effect of hyperbaric oxygenation on intervertebral disc degeneration: an in vivo study with sprague-dawley rats.
23093068J. Cereb. Blood Flow Metab.2013Muzzi M et al.Neurological basis of AMP-dependent thermoregulation and its relevance to central and peripheral hyperthermia.
23089186Prostaglandins Leukot. Essent. Fatty Acids2012Eilati E et al.Age dependent increase in prostaglandin pathway coincides with onset of ovarian cancer in laying hens.
22995857Nitric Oxide2013Alves DP et al.NO/cGMP production is important for the endogenous peripheral control of hyperalgesia during inflammation.
22985876Eur J Pharm Sci2012Komatsu T and Sakurada TComparison of the efficacy and skin permeability of topical NSAID preparations used in Europe.
22969117Cancer Discov2012Räsänen K and Herlyn MParacrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition.
22914655J. Neurophysiol.2012Alvarez P et al.IB4(+) nociceptors mediate persistent muscle pain induced by GDNF.
22773695Am. J. Physiol. Lung Cell Mol. Physiol.2012Lin CC et al.Adenosine triphosphate regulates NADPH oxidase activity leading to hydrogen peroxide production and COX-2/PGE2 expression in A549 cells.
22637723J. Pharmacol. Exp. Ther.2012Rim HK et al.Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock.
22614640Ann Biomed Eng2012Speich JE et al.Carbachol-induced volume adaptation in mouse bladder and length adaptation via rhythmic contraction in rabbit detrusor.
22613214Food Chem. Toxicol.2012Kaur G and Sultana SEvaluation of antiarthritic activity of isoeugenol in adjuvant induced arthritis in murine model.
22566780ScientificWorldJournal2012Hamed MA et al.Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats.
22565056Cell. Immunol.Bruckner M et al.Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E(2).
22537108J. Neurochem.2012Shin JH et al.Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
22511203J. Pharmacol. Exp. Ther.2012Bauer J et al.Carnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.
22394009J. Dermatol.2012Sato T et al.Novel anti-acne actions of nadifloxacin and clindamycin that inhibit the production of sebum, prostaglandin E(2) and promatrix metalloproteinase-2 in hamster sebocytes.
22360889BMB Rep2012Bae DS et al.Protopine reduces the inflammatory activity of lipopolysaccharide-stimulated murine macrophages.
22335196J. Pineal Res.2012Wang J et al.Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells.
22333568Biochem. Biophys. Res. Commun.2012Hegyi B et al.Activated T-cells and pro-inflammatory cytokines differentially regulate prostaglandin E2 secretion by mesenchymal stem cells.
22298530Am. J. Respir. Cell Mol. Biol.2012Nakanishi M et al.Prostaglandin E2 stimulates the production of vascular endothelial growth factor through the E-prostanoid-2 receptor in cultured human lung fibroblasts.
22222874Int. J. Hematol.2012Rouaud P et al.mPGES-1 in leukemic cells of AML patients.
22178799Resuscitation2012Walsh P et al.A matched case control study with propensity score balancing examining the protective effect of paracetamol against parentally reported apnoea in infants.
22178003Prostaglandins Other Lipid Mediat.2012Ells R et al.Sciadonic acid modulates prostaglandin E2 production by epithelial cells during infection with C. albicans and C. dubliniensis.
22133644Phytochemistry2012Zhang X et al.Bauer ketones 23 and 24 from Echinacea paradoxa var. paradoxa inhibit lipopolysaccharide-induced nitric oxide, prostaglandin E2 and cytokines in RAW264.7 mouse macrophages.
22129624Cytokine2012Whiley RA et al.Candida albicans strain-dependent modulation of pro-inflammatory cytokine release by in vitro oral and vaginal mucosal models.
22101002Prostaglandins Other Lipid Mediat.2012Ferreri NR et al.Eicosanoids and tumor necrosis factor-alpha in the kidney.
22048090J Bone Joint Surg Am2011Stålman A et al.Temperature-sensitive release of prostaglandin E₂ and diminished energy requirements in synovial tissue with postoperative cryotherapy: a prospective randomized study after knee arthroscopy.
22034631Blood2011Sarkar D et al.Engineered cell homing.
22001217Pharmacol. Res.2012Calvello R et al.Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.
21957456PLoS ONE2011Rudnick JA et al.Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.
21951555Am. J. Reprod. Immunol.2012Soleymaninejadian E et al.Immunomodulatory properties of mesenchymal stem cells: cytokines and factors.
21946663Immunol. Cell Biol.2012Sreeramkumar V et al.Prostaglandin E2 and T cells: friends or foes?
21907186Biochem. Biophys. Res. Commun.2011Choi HJ et al.Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
21884514Clin Transl Sci2011Barrie A et al.Prostaglandin E2 and IL-23 plus IL-1β differentially regulate the Th1/Th17 immune response of human CD161(+) CD4(+) memory T cells.
21880869J. Pharmacol. Exp. Ther.2011Impellizzeri D et al.Oleuropein aglycone, an olive oil compound, ameliorates development of arthritis caused by injection of collagen type II in mice.
21872518J Pediatr Adolesc Gynecol2011Kauschansky A et al.Insight: prolonged vaginal bleeding during central precocious puberty therapy with a long-acting gonadotropin-releasing hormone agonist: a proposed mechanism and management plan.
21801847Prostaglandins Other Lipid Mediat.2011Swan CE and Breyer RMProstaglandin E2 modulation of blood pressure homeostasis: studies in rodent models.
21784115Neurochem. Int.2011Takemiya TProstaglandin E2 produced by microsomal prostaglandin E synthase-1 regulates the onset and the maintenance of wakefulness.
21781136J. Vet. Pharmacol. Ther.2012Pelligand L et al.Development and validation of a tissue cage model of acute inflammation in the cat.
21745583Osteoarthr. Cartil.2011Attur M et al.Glatiramer acetate (GA), the immunomodulatory drug, inhibits inflammatory mediators and collagen degradation in osteoarthritis (OA) cartilage.
21596094Neurosci. Lett.2011Rusyniak DE et al.The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
21527345Pharmacol. Res.2011Singh P et al.Melatonin independent protective role of l-tryptophan in experimental reflux esophagitis in rats.
21376752Neurotoxicology2011Milatovic D et al.Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity.
21308823Phytother Res2011Li H et al.In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens.
21298639Laryngoscope2011Branski RC et al.The effects of cigarette smoke condensate on vocal fold transepithelial resistance and inflammatory signaling in vocal fold fibroblasts.
21292288Phytochemistry2011Shyur LF et al.A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression.
21277243Eur J Pain2011Diers M et al.Differential central pain processing following repetitive intramuscular proton/prostaglandin E₂ injections in female fibromyalgia patients and healthy controls.
21267839Tunis Med2011Jnifen A et al.[Cardiac arrest associated with sulprostone use during cesarean section].
21216219Arch. Biochem. Biophys.2011Líbano-Soares JD et al.Prostaglandin E₂ modulates proximal tubule Na+-ATPase activity: cooperative effect between protein kinase A and protein kinase C.
21199162Respirology2011Zhang W et al.Cigarette smoke modulates PGE(2) and host defence against Moraxella catarrhalis infection in human airway epithelial cells.
21177120Cytokine2011Osborn O et al.Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.
21111772Mol. Cell. Endocrinol.2011Lee J et al.Selective inhibition of prostaglandin E2 receptors EP2 and EP4 inhibits invasion of human immortalized endometriotic epithelial and stromal cells through suppression of metalloproteinases.
21077941Fundam Clin Pharmacol2011Zhang X et al.Effects of florfenicol on LPS-induced nitric oxide and prostaglandin E₂ production in RAW 264.7 macrophages.
21075387J. Urol.2011Tanaka I et al.Modulation of stretch evoked adenosine triphosphate release from bladder epithelium by prostaglandin E₂.
21062968J. Pharmacol. Exp. Ther.2011Park SW et al.The effects of the stromal cell-derived cyclooxygenase-2 metabolite prostaglandin E2 on the proliferation of colon cancer cells.
20969958Pharmacol. Res.2011Fornai M et al.Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
20947153J. Allergy Clin. Immunol.2010Ueta M et al.Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study.
20932983Neuropharmacology2011Järvelä JT et al.Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death.
20883838Acta Biomater2011Kim KS et al.Injectable hyaluronic acid-tyramine hydrogels for the treatment of rheumatoid arthritis.
20823759Anesthesiology2010Liang DY et al.Caspase-1 modulates incisional sensitization and inflammation.
20718752Br. J. Pharmacol.2010Mori S et al.Ciprofloxacin inhibits advanced glycation end products-induced adhesion molecule expression on human monocytes.
20692534ImmunobiologyWu WK et al.IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia.
20630498Arch. Oral Biol.2010Zhang F et al.IL-17A stimulates the expression of inflammatory cytokines via celecoxib-blocked prostaglandin in MC3T3-E1 cells.
20557877Cell. Immunol.2010Liu J et al.Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells.
20557444J. Vet. Pharmacol. Ther.2010Briston L et al.Age-related differences in prostaglandin E2 synthesis by equine cartilage explants and synoviocytes.
20553183J Med Food2010Choi SY et al.Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica.
20552344Methods Mol. Biol.2010Ferrario A and Gomer CJTargeting the tumor microenvironment using photodynamic therapy combined with inhibitors of cyclooxygenase-2 or vascular endothelial growth factor.
20546941J. Neuroimmunol.2010Soriano RN and Branco LGReduced stress fever is accompanied by increased glucocorticoids and reduced PGE2 in adult rats exposed to endotoxin as neonates.
20079660Trends Endocrinol. Metab.2010Blackwell KA et al.Prostaglandins in bone: bad cop, good cop?
20004474Mol. Immunol.2010Kim Y et al.Transglutaminase II interacts with rac1, regulates production of reactive oxygen species, expression of snail, secretion of Th2 cytokines and mediates in vitro and in vivo allergic inflammation.
19969421Pain2010Pinto LG et al.IL-17 mediates articular hypernociception in antigen-induced arthritis in mice.
19896488Life Sci.2009Villarreal CF et al.Acute and persistent nociceptive paw sensitisation in mice: the involvement of distinct signalling pathways.
19788928Int. J. Biochem. Cell Biol.2010Legler DF et al.Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances.
19545899Mol. Immunol.2009Côté SC et al.CCR7-specific migration to CCL19 and CCL21 is induced by PGE(2) stimulation in human monocytes: Involvement of EP(2)/EP(4) receptors activation.
19541354J. Allergy Clin. Immunol.2009Honda T et al.Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity.
19527795Prostaglandins Other Lipid Mediat.2009Nögel SC et al.Parecoxib does not suppress thromboxane synthesis in newborn piglets with group B streptococcal sepsis.
19524109Neurochem. Int.2009Andrade da Costa BL et al.The localization of PGE2 receptor subtypes in rat retinal cultures and the neuroprotective effect of the EP2 agonist butaprost.
19467701Biomaterials2009Chang MC et al.The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways.
19464664Prostaglandins Other Lipid Mediat.2009Kojima F et al.Prostaglandin E2 activates Rap1 via EP2/EP4 receptors and cAMP-signaling in rheumatoid synovial fibroblasts: involvement of Epac1 and PKA.
19447216Osteoarthr. Cartil.2009Liu YZ et al.Contribution of calcium-containing crystals to cartilage degradation and synovial inflammation in osteoarthritis.
19376214Toxicol. Lett.2009Ridley W and Matsuoka MFluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.
19233324Bone2009Minamizaki T et al.EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.
19203800J. Neuroimmunol.2009Saleem S et al.Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia.
19181340J. Surg. Res.2009Lai YC et al.Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages.
18986645Arch. Oral Biol.2009Katono T et al.Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts.
18848892Neurobiol. Dis.2008Wu Z et al.Age-dependent responses of glial cells and leptomeninges during systemic inflammation.
18786748Neurobiol. Aging2010Ma W et al.Injured nerve-derived COX2/PGE2 contributes to the maintenance of neuropathic pain in aged rats.
18632314J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.2008Neale JR and Dean BJLiquid chromatography-tandem mass spectrometric quantification of the dehydration product of tetranor PGE-M, the major urinary metabolite of prostaglandin E(2) in human urine.
18547825Osteoarthr. Cartil.2008Alvarez-Soria MA et al.Long-term NSAID treatment directly decreases COX-2 and mPGES-1 production in the articular cartilage of patients with osteoarthritis.
18539343Trends Pharmacol. Sci.2008Gresele P et al.Potentiation and priming of platelet activation: a potential target for antiplatelet therapy.
18486959Ultrasonics2008Pounder NM and Harrison AJLow intensity pulsed ultrasound for fracture healing: a review of the clinical evidence and the associated biological mechanism of action.
18472001Clin. Biochem.2008Kardeşler L et al.Gingival crevicular fluid PGE2, IL-1beta, t-PA, PAI-2 levels in type 2 diabetes and relationship with periodontal disease.
18400213Brain Res.2008Ma K et al.TTX-R Na+ current-reduction by celecoxib correlates with changes in PGE(2) and CGRP within rat DRG neurons during acute incisional pain.
18178094Neurobiol. Dis.2008Zhou P et al.Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway.
18164693Biochem. Pharmacol.2008Song HY et al.Topical transduction of superoxide dismutase mediated by HIV-1 Tat protein transduction domain ameliorates 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
18164360Toxicol. Appl. Pharmacol.2008Grauer E et al.Single whole-body exposure to sarin vapor in rats: long-term neuronal and behavioral deficits.
18021770Exp. Cell Res.2008Brock TG et al.Effects of prostaglandin E2 on the subcellular localization of Epac-1 and Rap1 proteins during Fcgamma-receptor-mediated phagocytosis in alveolar macrophages.
17923400Prostaglandins Leukot. Essent. Fatty AcidsAimbire F et al.Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation.
17707592Burns2007Summer GJ et al.Enhanced inflammatory hyperalgesia after recovery from burn injury.
17678966Int. Rev. Neurobiol.2007Minghetti L and Pocchiari MCyclooxygenase-2, prostaglandin E2, and microglial activation in prion diseases.
17643883Prostaglandins Other Lipid Mediat.2007Antonucci R et al.Urinary prostaglandin E2 in the newborn and infant.
17637821J. Invest. Dermatol.2008Sur R et al.Anti-inflammatory activity of sertaconazole nitrate is mediated via activation of a p38-COX-2-PGE2 pathway.
17517372Biochem. Biophys. Res. Commun.2007Hennerbichler A et al.Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression.
17493609Exp. Cell Res.2007Birukova AA et al.Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.
17275922J. Neuroimmunol.2007Ahmad M et al.Stimulation of prostaglandin E2-EP3 receptors exacerbates stroke and excitotoxic injury.
17088072Cytokine2006Melgar S et al.Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis.
16859832Biochim. Biophys. Acta2006Chell S et al.Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.
16751012J. Allergy Clin. Immunol.2006Trudeau J et al.Selective downregulation of prostaglandin E2-related pathways by the Th2 cytokine IL-13.
16698015Exp. Eye Res.2006Ilieva I et al.Captopril suppresses inflammation in endotoxin-induced uveitis in rats.
16635738Phytomedicine2006Takano-Ishikawa Y et al.Structure-activity relations of inhibitory effects of various flavonoids on lipopolysaccharide-induced prostaglandin E2 production in rat peritoneal macrophages: comparison between subclasses of flavonoids.
16487663Burns2006Yeh FL et al.Keloid-derived fibroblasts have a diminished capacity to produce prostaglandin E2.
16413466Cancer Cell2006Buchanan FG and DuBois RNConnecting COX-2 and Wnt in cancer.
16337744Cancer Treat. Rev.2006Wu TCyclooxygenase-2 in hepatocellular carcinoma.
16324819Microb. Pathog.2006Jobin MC et al.Upregulation of prostaglandin E2 and matrix metalloproteinase 9 production by human macrophage-like cells: synergistic effect of capsular material and cell wall from Streptococcus suis.
16309673Exp. Eye Res.2006Jin XH et al.Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopolysaccharide-induced inflammation in vitro and in vivo.
16297651Microbes Infect.2006Liu W et al.COX-2 inhibition affects growth rate of Chlamydia muridarum within epithelial cells.
16289620Life Sci.2006Shoji M et al.Lipopolysaccharide stimulates the production of prostaglandin E2 and the receptor Ep4 in osteoblasts.
16249720J Endod2005Alptekin NO et al.The effect of endodontic therapy on periapical exudate neutrophil elastase and prostaglandin-E2 levels.
16153871Microbes Infect.2006Bodet C et al.Inflammatory responses of a macrophage/epithelial cell co-culture model to mono and mixed infections with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia.
16023335Prostaglandins Leukot. Essent. Fatty Acids2005Myers SI et al.Cholecystokinin (CCK) down regulates PGE2 and PGI2 release in inflamed Guinea pig gallbladder smooth muscle cell cultures.
15978547Biochem. Pharmacol.2005Zeddou M et al.Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway.
15936882Pain2005Costa B et al.Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.
15831295Fertil. Steril.2005Saed GM et al.Hypoxia upregulates cyclooxygenase-2 and prostaglandin E(2) levels in human peritoneal fibroblasts.
15804596Cytokine2005Belibasakis GN et al.Cytokine responses of human gingival fibroblasts to Actinobacillus actinomycetemcomitans cytolethal distending toxin.
15781270Biochem. Biophys. Res. Commun.2005McGarry JG et al.The effect of cytoskeletal disruption on pulsatile fluid flow-induced nitric oxide and prostaglandin E2 release in osteocytes and osteoblasts.
15694412Biochem. Biophys. Res. Commun.2005Clark CA et al.Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.
15683683Burns2005Luo G et al.The role of NO in macrophage dysfunction at early stage after burn injury.
15639640Osteoarthr. Cartil.2005Mathy-Hartert M et al.Influence of oxygen tension on nitric oxide and prostaglandin E2 synthesis by bovine chondrocytes.
15350824Life Sci.2004Sakaguchi Y et al.Effects of selective iNOS inhibition on type II collagen-induced arthritis in mice.
15331400Am. J. Pathol.2004Wilgus TA et al.The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing.
15325565Exp. Eye Res.2004Ilieva I et al.The effects of Ginkgo biloba extract on lipopolysaccharide-induced inflammation in vitro and in vivo.
15313472Int. J. Biochem. Cell Biol.2004Park YG et al.Effects of TGF-beta, TNF-alpha, IL-beta and IL-6 alone or in combination, and tyrosine kinase inhibitor on cyclooxygenase expression, prostaglandin E2 production and bone resorption in mouse calvarial bone cells.
15304095J. Invest. Dermatol.2004Kim HJ and Kim TYIGF-II-mediated COX-2 gene expression in human keratinocytes through extracellular signal-regulated kinase pathway.
15275861Arch. Oral Biol.2004Miyauchi M et al.Immuno-localization of COX-1 and COX-2 in the rat molar periodontal tissue after topical application of lipopolysaccharide.
15196696Mol. Cell. Endocrinol.2004Andersson AK et al.Cytokine-induced PGE(2) formation is reduced from iNOS deficient murine islets.
14987993FEBS Lett.2004Bradbury DA et al.PI 3-kinase and MAP kinase regulate bradykinin induced prostaglandin E(2) release in human pulmonary artery by modulating COX-2 activity.
14643689Pharmacol. Res.2004Klein AL et al.The cyclooxygenase-2 product prostaglandin E2 modulates cardiac contractile function in adult rat ventricular cardiomyocytes.
14580365Prostaglandins Leukot. Essent. Fatty Acids2003Wegmann M and Nüsing RMProstaglandin E2 stimulates sodium reabsorption in MDCK C7 cells, a renal collecting duct principal cell model.
14518562Prostaglandins Other Lipid Mediat.2003Takemiya T et al.Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling.
12957128J. Surg. Res.2003Lo CJMAPK regulation of prostaglandin E2 production by lipopolysaccharide-stimulated macrophages is not dependent on nuclear factor kappaB.
12907132Prostaglandins Leukot. Essent. Fatty Acids2003Miyazaki M et al.Macrolide antibiotics inhibit prostaglandin E2 synthesis and mRNA expression of prostaglandin synthetic enzymes in human leukocytes.
12718940Cell. Immunol.2002Alexander M et al.Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury.
12631112Kidney Int.2003Yamagishi S et al.Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells.
12517400Theriogenology2003Brinsko SP et al.Pregnancy rates in mares following hysteroscopic or transrectally-guided insemination with low sperm numbers at the utero-tubal papilla.
12493622Brain Res.2003Yagami T et al.Prostaglandin E2 rescues cortical neurons from amyloid beta protein-induced apoptosis.
12479978Life Sci.2003Segawa M et al.Angiotensin II induces prostaglandin E(2) release in human gingival fibroblasts.
12404228Gastroenterology2002Berg DJ et al.Rapid development of colitis in NSAID-treated IL-10-deficient mice.
12231413Bone2002Mo A et al.Bipedal stance exercise and prostaglandin E2 (PGE2) and its synergistic effect in increasing bone mass and in lowering the PGE2 dose required to prevent ovariectomized-induced cancellous bone loss in aged rats.
12128157Brain Res. Bull.2002Yamaguchi K and Watanabe KContribution of N-methyl-d-aspartate receptors in the anteroventral third ventricular region to vasopressin secretion, but not to cardiovascular responses provoked by hyperosmolality and prostaglandin E2 in conscious rats.
12105834Gastroenterology2002Kaur BS et al.Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus.
12055598Gastroenterology2002Sigthorsson G et al.COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.
12048117Atherosclerosis2002Garlichs CD et al.Induction of cyclooxygenase-2 and enhanced release of prostaglandin E(2) and I(2) in human endothelial cells by engagement of CD40.
12031786Pain2002Turnbach ME and Randich AThe role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
11973001Pain2002Southall MD et al.Twenty-four hour exposure to prostaglandin downregulates prostanoid receptor binding but does not alter PGE(2)-mediated sensitization of rat sensory neurons.
11738136Neuroscience2001Ben-Hur T et al.A novel permissive role for glucocorticoids in induction of febrile and behavioral signs of experimental herpes simplex virus encephalitis.
11586213J. Urol.2001Shahed AR and Shoskes DACorrelation of beta-endorphin and prostaglandin E2 levels in prostatic fluid of patients with chronic prostatitis with diagnosis and treatment response.
11375954Gastroenterology2001Barbara G et al.Role of immunologic factors and cyclooxygenase 2 in persistent postinfective enteric muscle dysfunction in mice.
11369112Toxicology2001Skoczyńska A et al.Lead-cadmium interaction effect on the responsiveness of rat mesenteric vessels to norepinephrine and angiotensin II.
10880739Hum. Immunol.2000Cosme R et al.Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression.
10560620Prostaglandins Other Lipid Mediat.1999Hishinuma T et al.Microdetermination of prostaglandin E2 in joint fluid in rheumatoid arthritis patients using gas chromatography/selected ion monitoring.
10560618Prostaglandins Other Lipid Mediat.1999Wiercińska-Drapało A et al.Effects of ulcerative colitis activity on plasma and mucosal prostaglandin E2 concentration.
10560612Prostaglandins Other Lipid Mediat.1999Lin WW et al.Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: distinct susceptibility in murine J774 and RAW 264.7 macrophages.
10521746Am. J. Obstet. Gynecol.1999Ravasia DJ et al.Incidence of uterine rupture among women with müllerian duct anomalies who attempt vaginal birth after cesarean delivery.
10403389FEBS Lett.1999Herencia F et al.Novel anti-inflammatory chalcone derivatives inhibit the induction of nitric oxide synthase and cyclooxygenase-2 in mouse peritoneal macrophages.
10400344Bioorg. Med. Chem.1999Gil L et al.Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.
10397448Cancer Lett.1998Kökoğlu E et al.Prostaglandin E2 levels in human brain tumor tissues and arachidonic acid levels in the plasma membrane of human brain tumors.
10392853Neuroscience1999Sauer SK et al.Rat peripheral nerve components release calcitonin gene-related peptide and prostaglandin E2 in response to noxious stimuli: evidence that nervi nervorum are nociceptors.
10216171Brain Res.1999Thornhill J and Asselin JThe effect of head cooling on the physiological responses and resultant neural damage to global hemispheric hypoxic ischemia in prostaglandin E2 treated rats.
9987068Kidney Int.1999Schneider A et al.Cyclooxygenase metabolites mediate glomerular monocyte chemoattractant protein-1 formation and monocyte recruitment in experimental glomerulonephritis.
9880106Vet. Immunol. Immunopathol.1998Yoshioka M et al.The release of tumor necrosis factor-alpha, interleukin-1, interleukin-6 and prostaglandin E2 in bovine Kupffer cells stimulated with bacterial lipopolysaccharide.
9847016Vet. Immunol. Immunopathol.1998Hawkins DL et al.Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages.
9767561Kidney Int.1998Kurtz IMolecular pathogenesis of Bartter's and Gitelman's syndromes.
9745362Trends Pharmacol. Sci.1998Folkerts G and Nijkamp FPAirway epithelium: more than just a barrier!
9744292Brain Res. Bull.1998Jaworowicz DJ et al.Nitric oxide and prostaglandin E2 formation parallels blood-brain barrier disruption in an experimental rat model of bacterial meningitis.
9737347Bone1998Ke HZ et al.Prostaglandin E2 increases bone strength in intact rats and in ovariectomized rats with established osteopenia.
9729377Brain Res. Mol. Brain Res.1998Liu Y et al.Taurine chloramine inhibits production of nitric oxide and prostaglandin E2 in activated C6 glioma cells by suppressing inducible nitric oxide synthase and cyclooxygenase-2 expression.
9626402Bone1998Fermor B et al.Primary human osteoblast proliferation and prostaglandin E2 release in response to mechanical strain in vitro.
9622592Biochim. Biophys. Acta1998Pruzanski W et al.Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth factors.
9369819Am. J. Obstet. Gynecol.1997Hannah ME et al.Maternal colonization with group B Streptococcus and prelabor rupture of membranes at term: the role of induction of labor. TermPROM Study Group.
9336579J Am Diet Assoc1997Peck LWEssential fatty acid deficiency in renal failure: can supplements really help?
9261861Prostaglandins1997Sánchez-Ramírez B et al.Role of prostaglandin E2 on amoebic liver abscess formation in hamsters.
9134973Brain Res.1997Williams A et al.Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations.
7572849Am J Orthod Dentofacial Orthop1995Leiker BJ et al.The effects of exogenous prostaglandins on orthodontic tooth movement in rats.