PGD2

Pgd2 is a lipid of Fatty Acyls (FA) class. Pgd2 is associated with abnormalities such as Inflammatory disorder, Pleurisy, Rhinitis, Dehydration and Pneumonia. The involved functions are known as antagonists, fat cell differentiation, Phosphorylation, Process and Gene Expression. Pgd2 often locates in Cell surface, Body tissue, Extracellular, Bone Marrow and Membrane. The associated genes with PGD2 are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, P4HTM gene, PTGS2 gene, PTGDS gene and IL3 gene. The related lipids are 15-deoxyprostaglandin J2, Nonesterified Fatty Acids, Lipopolysaccharides, Steroids and Liposomes. The related experimental models are Knock-out and Rodent Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
380688	Blood	1979	Cooper B	Diminished platelet adenylate cyclase activation by prostaglandin D2 in acute thrombosis.
16418339	Mol. Pharmacol.	2006	Mathiesen JM et al.	On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.
27621415	J. Exp. Med.	2016	Kong D et al.	PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.
27091669	Allergol Int	2016	Kanai K et al.	Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.
26945085	J. Pharmacol. Exp. Ther.	2016	Nagira Y et al.	Prostaglandin D2 Modulates Neuronal Excitation of the Trigeminal Ganglion to Augment Allergic Rhinitis in Guinea Pigs.
26916831	Mol. Pharmacol.	2016	Sykes DA et al.	Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.
26801686	Biochem. Pharmacol.	2016	Koyani CN et al.	Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death.
25323233	Eur. Respir. J.	2015	Maher SA et al.	Prostaglandin D2 and the role of the DP1, DP2 and TP receptors in the control of airway reflex events.
25269616	Reproduction	2015	Rossitto M et al.	Multiple roles of the prostaglandin D2 signaling pathway in reproduction.
25159329	Am. J. Physiol. Endocrinol. Metab.	2014	Cantley JL et al.	Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats.
24698234	Int. J. Cardiol.	2014	Koyani CN et al.	15-deoxy-Δ¹²,¹⁴-PGJ₂ promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis.