20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
9223545 | J. Pharmacol. Exp. Ther. | 1997 | Askari B et al. | Analysis of eicosanoid mediation of the renal functional effects of hyperchloremia. |
9688677 | Am. J. Physiol. | 1998 | Su P et al. | Inhibition of renal arachidonic acid omega-hydroxylase activity with ABT reduces blood pressure in the SHR. |
10070137 | Am. J. Physiol. | 1999 | Oyekan AO et al. | Endothelin-1 and CYP450 arachidonate metabolites interact to promote tissue injury in DOCA-salt hypertension. |
10484476 | Am. J. Physiol. | 1999 | McGiff JC and Quilley J | 20-HETE and the kidney: resolution of old problems and new beginnings. |
9831701 | Circ. Res. | 1998 | Sun CW et al. | Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. |
9950890 | Am. J. Physiol. | 1999 | Jacobs ER et al. | Airway synthesis of 20-hydroxyeicosatetraenoic acid: metabolism by cyclooxygenase to a bronchodilator. |
9950955 | Am. J. Physiol. | 1999 | Wang MH et al. | Contribution of cytochrome P-450 4A1 and 4A2 to vascular 20-hydroxyeicosatetraenoic acid synthesis in rat kidneys. |
11739122 | Am. J. Physiol. Renal Physiol. | 2002 | Escalante BA et al. | Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. |
11303033 | J. Pharmacol. Exp. Ther. | 2001 | Yaghi A et al. | Cytochrome P450 metabolites of arachidonic acid but not cyclooxygenase-2 metabolites contribute to the pulmonary vascular hyporeactivity in rats with acute Pseudomonas pneumonia. |
11320253 | Proc. Natl. Acad. Sci. U.S.A. | 2001 | Holla VR et al. | Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. |
11208597 | Am. J. Physiol. Renal Physiol. | 2001 | Gu R et al. | Role of 20-HETE in mediating the effect of dietary K intake on the apical K channels in the mTAL. |
12060587 | Am. J. Physiol. Renal Physiol. | 2002 | Marji JS et al. | Cytochrome P-450 4A isoform expression and 20-HETE synthesis in renal preglomerular arteries. |
12419775 | Am. J. Physiol. Renal Physiol. | 2003 | Cheng MK et al. | Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase. |
12677022 | Stroke | 2003 | Cambj-Sapunar L et al. | Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. |
12754190 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2003 | Cloutier M et al. | 20-HETE inotropic effects involve the activation of a nonselective cationic current in airway smooth muscle. |
12566369 | Circulation | 2003 | Laffer CL et al. | Differential regulation of natriuresis by 20-hydroxyeicosatetraenoic Acid in human salt-sensitive versus salt-resistant hypertension. |
10836982 | Am. J. Physiol. Renal Physiol. | 2000 | Quigley R et al. | Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport. |
10966934 | Am. J. Physiol. Renal Physiol. | 2000 | Croft KD et al. | Angiotensin II releases 20-HETE from rat renal microvessels. |
10992547 | Thorax | 2000 | Carroll MA and McGiff JC | A new class of lipid mediators: cytochrome P450 arachidonate metabolites. |
10362756 | Am. J. Physiol. | 1999 | Ito O and Roman RJ | Regulation of P-450 4A activity in the glomerulus of the rat. |
9618440 | J. Pharmacol. Exp. Ther. | 1998 | Powell PK et al. | Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11. |
14612451 | J. Biol. Chem. | 2004 | Kaduce TL et al. | 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. |
14634044 | J. Pharmacol. Exp. Ther. | 2004 | Xu F et al. | Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. |
15316085 | J. Pharmacol. Exp. Ther. | 2004 | Zhao X et al. | P2X receptor-stimulated calcium responses in preglomerular vascular smooth muscle cells involves 20-hydroxyeicosatetraenoic acid. |
15262846 | Circulation | 2004 | Ward NC et al. | Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. |
14709657 | Clin. Chem. | 2004 | Rivera J et al. | Measurement of 20-hydroxyeicosatetraenoic acid in human urine by gas chromatography-mass spectrometry. |
20837537 | Proc. Natl. Acad. Sci. U.S.A. | 2010 | Liu JY et al. | Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. |
21617146 | Stroke | 2011 | Crago EA et al. | Cerebrospinal fluid 20-HETE is associated with delayed cerebral ischemia and poor outcomes after aneurysmal subarachnoid hemorrhage. |
18842817 | Am. J. Physiol. Renal Physiol. | 2008 | Williams JM et al. | Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury. |
19443836 | Circ. Res. | 2009 | Inoue R et al. | Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via phospholipase C/diacylglycerol and phospholipase A2/omega-hydroxylase/20-HETE pathways. |
19570883 | Am. J. Physiol. Renal Physiol. | 2009 | Akbulut T et al. | 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. |
19675180 | Am. J. Physiol. Renal Physiol. | 2009 | Inoue K et al. | Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE. |
19841472 | J. Pharmacol. Exp. Ther. | 2010 | Cheng J et al. | 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. |
19846914 | Anticancer Res. | 2009 | Alexanian A et al. | Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth. |
20061439 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2010 | Bodiga S et al. | 20-HETE-induced nitric oxide production in pulmonary artery endothelial cells is mediated by NADPH oxidase, H2O2, and PI3-kinase/Akt. |
17507602 | Am. J. Physiol. Renal Physiol. | 2007 | Williams JM et al. | Role of endogenous CYP450 metabolites of arachidonic acid in maintaining the glomerular protein permeability barrier. |
17660330 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2007 | Morin C et al. | Functional effects of 20-HETE on human bronchi: hyperpolarization and relaxation due to BKCa channel activation. |
18171997 | Am. J. Physiol. Renal Physiol. | 2008 | Nilakantan V et al. | 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells. |
18235092 | J. Am. Soc. Nephrol. | 2008 | Liu H et al. | Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. |
15821014 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2005 | Parker TA et al. | Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. |
15831442 | J. Pharmacol. Exp. Ther. | 2005 | Miyata N et al. | Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke. |
15639488 | Cardiovasc. Res. | 2005 | Randriamboavonjy V et al. | The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. |
16396943 | Am. J. Physiol. Renal Physiol. | 2006 | Roman RJ et al. | Characterization of blood pressure and renal function in chromosome 5 congenic strains of Dahl S rats. |
16339392 | J. Pharmacol. Exp. Ther. | 2006 | Zhou Y et al. | Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. |
16081420 | J. Biol. Chem. | 2005 | Collins XH et al. | Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. |
16055480 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2005 | Yaghi A and Sims SM | Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. |
15998843 | Am. J. Physiol. Renal Physiol. | 2005 | Huang H et al. | Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by L-NAME treatment in pregnant rats. |
16543501 | Circ. Res. | 2006 | Wang JS et al. | Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus. |
16775295 | AJNR Am J Neuroradiol | 2006 Jun-Jul | Hacein-Bey L et al. | Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. |
16601220 | Stroke | 2006 | Omura T et al. | Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. |
16166237 | J. Appl. Physiol. | 2006 | Qin X et al. | Role of 20-HETE in the pial arteriolar constrictor response to decreased hematocrit after exchange transfusion of cell-free polymeric hemoglobin. |
17210799 | J. Pharmacol. Exp. Ther. | 2007 | Guo AM et al. | Activation of vascular endothelial growth factor through reactive oxygen species mediates 20-hydroxyeicosatetraenoic acid-induced endothelial cell proliferation. |
18596124 | J. Am. Soc. Nephrol. | 2008 | Park F et al. | 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. |
18725506 | Drug Metab. Dispos. | 2008 | Mu Y et al. | Intravenous formulation of N-hydroxy-N'-(4-n-butyl-2-methylphenyl)formamidine (HET0016) for inhibition of rat brain 20-hydroxyeicosatetraenoic acid formation. |
22723444 | Arterioscler. Thromb. Vasc. Biol. | 2012 | Cheng J et al. | Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. |
23641057 | J. Am. Soc. Nephrol. | 2013 | Wu CC et al. | Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. |
23658377 | J. Pharmacol. Exp. Ther. | 2013 | Orozco LD et al. | 20-Hydroxyeicosatetraenoic acid inhibition attenuates balloon injury-induced neointima formation and vascular remodeling in rat carotid arteries. |
23392684 | J. Neurosci. | 2013 | Fordsmann JC et al. | Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex. |
23966667 | J. Lipid Res. | 2013 | Van Bogaert I et al. | Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. |
25526688 | Prostaglandins Other Lipid Mediat. | 2015 Jan-Mar | Garcia V et al. | Androgen-induced hypertension in angiotensinogen deficient mice: role of 20-HETE and EETS. |
24990891 | Am. J. Physiol. Renal Physiol. | 2014 | Ren Y et al. | Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive rats: role of 20-HETE. |
27559173 | J. Neurosci. | 2016 | Ziegler N et al. | β-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. |
27528620 | Mol. Cell. Biol. | 2016 | Garbacz WG et al. | Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance. |
27194719 | Am. J. Physiol. Renal Physiol. | 2016 | Dalmasso C et al. | 20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats. |
27084395 | Vascul. Pharmacol. | 2016 | Chen L et al. | 20-HETE contributes to ischemia-induced angiogenesis. |
26747234 | Prostaglandins Other Lipid Mediat. | 2016 | Huang H et al. | Cyclooxygenase- and cytochrome P450-derived eicosanoids in stroke. |
26699146 | J. Pharmacol. Exp. Ther. | 2016 | Garcia V et al. | 20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding. |
25908301 | Prostaglandins Other Lipid Mediat. | 2015 | Vanella L et al. | Soluble epoxide hydrolase null mice exhibit female and male differences in regulation of vascular homeostasis. |
25813407 | Prostaglandins Other Lipid Mediat. | 2015 | Hoopes SL et al. | Vascular actions of 20-HETE. |
25644108 | J. Am. Soc. Nephrol. | 2015 | Muroya Y et al. | Deficiency in the Formation of 20-Hydroxyeicosatetraenoic Acid Enhances Renal Ischemia-Reperfusion Injury. |
25447342 | Prostaglandins Other Lipid Mediat. | 2015 Jan-Mar | McCarthy ET et al. | Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. |
25249502 | J. Lipid Res. | 2014 | Jarrar YB et al. | Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation. |
25071086 | J. Am. Soc. Nephrol. | 2015 | Gangadhariah MH et al. | Hypertension is a major contributor to 20-hydroxyeicosatetraenoic acid-mediated kidney injury in diabetic nephropathy. |
25007877 | Am. J. Physiol. Renal Physiol. | 2014 | Ge Y et al. | Role of 20-HETE in the impaired myogenic and TGF responses of the Af-Art of Dahl salt-sensitive rats. |