rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
11739733	Mol. Cell. Biol.	2002	Blass M et al.	Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide.
11313407	J. Immunol.	2001	Solomou EE et al.	Protein kinase C-theta participates in the activation of cyclic AMP-responsive element-binding protein and its subsequent binding to the -180 site of the IL-2 promoter in normal human T lymphocytes.
12117979	Infect. Immun.	2002	Wadsworth SJ and Goldfine H	Mobilization of protein kinase C in macrophages induced by Listeria monocytogenes affects its internalization and escape from the phagosome.
12657722	Mol. Cancer Ther.	2003	McCracken MA et al.	Protein kinase C delta is a prosurvival factor in human breast tumor cell lines.
19279100	J. Virol.	2009	Raghu H et al.	Kaposi's sarcoma-associated herpesvirus utilizes an actin polymerization-dependent macropinocytic pathway to enter human dermal microvascular endothelial and human umbilical vein endothelial cells.
19037087	Carcinogenesis	2009	Lim JH et al.	Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.
20395372	J. Am. Soc. Nephrol.	2010	Li X et al.	PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.
21911819	Circulation	2011	Clements RT et al.	Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts.
17901241	J. Appl. Physiol.	2007	Klinger JR et al.	Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.
17374730	Mol. Cancer Res.	2007	Akar U et al.	Tissue transglutaminase inhibits autophagy in pancreatic cancer cells.
17625040	Am. J. Physiol., Cell Physiol.	2007	Wang Y et al.	Advanced glycation end products elicit externalization of phosphatidylserine in a subpopulation of platelets via 5-HT2A/2C receptors.
18083882	Appl. Environ. Microbiol.	2008	Shivshankar P et al.	Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells.
15817518	Brain	2005	Obreja O et al.	Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.
14996912	J. Cell. Sci.	2004	Frank DE and Carter WG	Laminin 5 deposition regulates keratinocyte polarization and persistent migration.
23995289	FASEB J.	2013	Goldklang MP et al.	Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties.