hypericin

hypericin is a lipid of Polyketides (PK) class. Hypericin is associated with abnormalities such as Dermatitis, Phototoxic, Dehydration, Photosensitization, Morphologically altered structure and Myocardial Infarction. The involved functions are known as Cell Cycle Checkpoints, Apoptosis, Acetylation, Cell Survival and Caspase Activation. Hypericin often locates in insoluble fraction, Cytoplasmic matrix, Protoplasm, Tissue membrane and Cytoplasm. The associated genes with hypericin are CDC37 gene, HSPA8 gene, RAF1 gene, cyclin H and FK228. The related lipids are Phosphatidylserines.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
10744649	Int. Immunol.	2000	Lavie G et al.	Inhibition of the CD8+ T cell-mediated cytotoxicity reaction by hypericin: potential for treatment of T cell-mediated diseases.
10799921	J. Immunol.	2000	Geng Y et al.	Chlamydia pneumoniae inhibits apoptosis in human peripheral blood mononuclear cells through induction of IL-10.
14678981	Cancer Res.	2003	Blank M et al.	Enhanced ubiquitinylation of heat shock protein 90 as a potential mechanism for mitotic cell death in cancer cells induced with hypericin.
21498539	J. Nucl. Med.	2011	Song S et al.	Small-animal PET of tumor damage induced by photothermal ablation with 64Cu-bis-DOTA-hypericin.
15640377	Drug Metab. Dispos.	2005	Tian R et al.	Functional induction and de-induction of P-glycoprotein by St. John's wort and its ingredients in a human colon adenocarcinoma cell line.