Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
20529838	J. Biol. Chem.	2010	Gao P et al.	The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells.
20032412	Anticancer Res.	2009	Xu P et al.	Mitogenic activity of zeranol in human breast cancer cells is enhanced by leptin and suppressed by gossypol.
22052903	J. Biol. Chem.	2012	Hu W et al.	Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.
18202226	Blood	2008	Kitada S et al.	Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).
15570010	Clin. Cancer Res.	2004	Oliver CL et al.	In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.
15849309	Plant Physiol.	2005	Townsend BJ et al.	Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression.
17162530	Toxicol Pathol	2006	de Andrade SF et al.	Epididymis-specific pathologic disorders in rats exposed to gossypol from weaning through puberty.
25802279	Mol. Cell. Biol.	2015	Hanus J et al.	Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.