Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
10516121	Am. J. Physiol.	1999	Horigome H et al.	Glycyrrhetinic acid-induced apoptosis in thymocytes: impact of 11beta-hydroxysteroid dehydrogenase inhibition.
11980696	Circulation	2002	Ferrari P	Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.
11007814	Nephrol. Dial. Transplant.	2000	Frey FJ and Ferrari P	Pastis and hypertension--what is the molecular basis?
9683905	Cardiovasc. Res.	1998	van Uum SH et al.	The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension.
17513608	Mol. Cancer Ther.	2007	Chintharlapalli S et al.	Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.
15788515	J. Neurophysiol.	2005	Vogalis F et al.	Electrical coupling in sustentacular cells of the mouse olfactory epithelium.
16002718	J. Immunol.	2005	Ukil A et al.	18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B.
25691644	Antimicrob. Agents Chemother.	2015	Gupta P et al.	Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation.