Sphinganine

Sphinganine is a lipid of Sphingolipids (SP) class. Sphinganine is associated with abnormalities such as Sphingolipidoses, CLEFT LIP, CONGENITAL HEALED, Aortic aneurysm, familial thoracic 4, Morphologically altered structure and Atherosclerosis. The involved functions are known as Transcription, Genetic, Signal, Muscle Contraction, biological adaptation to stress and Gene Expression. Sphinganine often locates in Tissue membrane, Membrane, Protoplasm, Plasma membrane and Cytoplasmic. The associated genes with Sphinganine are SLC33A1 gene, HM13 gene, P4HTM gene, SPHK1 gene and SPHK2 gene. The related lipids are Sphingolipids, Phosphatidylserines, Sterols, Fatty Acids and inositolphosphorylceramide. The related experimental models are Mouse Model and Knock-out.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
9582276	EMBO J.	1998	Meyer zu Heringdorf D et al.	Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors.
9915902	J. Nutr.	1999	Wang E et al.	Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine.
15229289	Mol. Biol. Cell	2004	Van IJzendoorn SC et al.	Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover.
17609357	J. Vet. Diagn. Invest.	2007	Hsiao SH et al.	Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine.
15545514	Circulation	2004	Park TS et al.	Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice.
22872679	FASEB J.	2012	Ashkenazi A et al.	Sphingopeptides: dihydrosphingosine-based fusion inhibitors against wild-type and enfuvirtide-resistant HIV-1.
12391098	J. Appl. Physiol.	2003	Ryan AJ et al.	Alveolar sphingolipids generated in response to TNF-alpha modifies surfactant biophysical activity.
26277409	Biochim. Biophys. Acta	2015	Megson ZA et al.	Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol.