sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

References related to abnormalities published in Others


PMIDJournalPublished DateAuthorTitle
19147754Clin. Cancer Res.2009Song Y et al.Sp-1 and c-Myc mediate lysophosphatidic acid-induced expression of vascular endothelial growth factor in ovarian cancer cells via a hypoxia-inducible factor-1-independent mechanism.
16987962Mol. Biol. Cell2006Eng CH et al.The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts.
7592645J. Biol. Chem.1995Seufferlein T and Rozengurt ESphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein.
9195933J. Biol. Chem.1997Lai TS et al.Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase.
21368227J. Immunol.2011Lee HY et al.Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.
16111665Cardiovasc. Res.2005Schubert RNon-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
18523246J. Immunol.2008Takenouchi T et al.Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.