PSYCHOSINE

PSYCHOSINE is a lipid of Sphingolipids (SP) class. Psychosine is associated with abnormalities such as Globoid cell leukodystrophy, Demyelinating Diseases, Multiple Sclerosis, nervous system disorder and Lysosomal Storage Diseases. The involved functions are known as Ionization, Pathogenesis, Demyelination, 5-(carboxyamino)imidazole ribonucleotide mutase activity and Increased Sensitivy. Psychosine often locates in Body tissue, CNS - Brain (MMHCC), Autosome, Peripheral Nervous System and Nerve Tissue. The associated genes with PSYCHOSINE are GALC gene, NTRK1 gene, JUN gene, ALPP gene and Polylysine. The related lipids are Fatty Acids, fatty aldehyde, lysophosphatidic acid, Stearic acid and stearoyl chloride. The related experimental models are Mouse Model and Streptozotocin Diabetes.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
11734583	J. Lipid Res.	2001	Whitfield PD et al.	Quantification of galactosylsphingosine in the twitcher mouse using electrospray ionization-tandem mass spectrometry.
11978730	FASEB J.	2002	Giri S et al.	Galactosylsphingosine (psychosine)-induced expression of cytokine-mediated inducible nitric oxide synthases via AP-1 and C/EBP: implications for Krabbe disease.
16382156	Mol. Cell. Biol.	2006	Radu CG et al.	Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.
18753677	J. Lipid Res.	2009	Jiang X et al.	Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard.
23983033	Brain	2013	Belleri M et al.	Inhibition of angiogenesis by β-galactosylceramidase deficiency in globoid cell leukodystrophy.
27170180	Mol. Biol. Cell	2016	Watanabe H et al.	Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulation of phosphoinositide 4,5-bisphosphate production at the cleavage furrow.
26359302	J. Cell. Sci.	2015	O'Sullivan C and Dev KK	Galactosylsphingosine (psychosine)-induced demyelination is attenuated by sphingosine 1-phosphate signalling.