25-Hydroxycholesterol
25-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 25-hydroxycholesterol is associated with abnormalities such as Hereditary Diseases, Atherosclerosis, Fatty Liver, Infection and Exanthema. The involved functions are known as Binding (Molecular Function), cholesterol binding, sterol binding, oxysterol binding and Regulation. 25-hydroxycholesterol often locates in Membrane, Golgi membrane, Cellular Membrane, Cytoplasmic matrix and Golgi Apparatus. The associated genes with 25-Hydroxycholesterol are PTPN7 gene, OSBP gene, N-glycylalanine, SCAP gene and TSPO gene. The related lipids are 25-hydroxycholesterol, Sterols, Hydroxycholesterols, 27-hydroxycholesterol and Steroids. The related experimental models are Knock-out.
References related to abnormalities published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 21123296 | J. Leukoc. Biol. | 2010 | McDonald JG and Russell DW | Editorial: 25-Hydroxycholesterol: a new life in immunology. |
| 18854425 | Am. J. Physiol. Endocrinol. Metab. | 2008 | Ma Y et al. | 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. |
| 15604201 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2005 | Alrefai WA et al. | Cholesterol modulates human intestinal sodium-dependent bile acid transporter. |
| 21979142 | Cardiovasc. Res. | 2012 | Wang F et al. | Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. |
| 18762023 | Cell Metab. | 2008 | Porstmann T et al. | SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. |
| 20227267 | Prostaglandins Leukot. Essent. Fatty Acids | 2010 Apr-Jun | Vallim T and Salter AM | Regulation of hepatic gene expression by saturated fatty acids. |
| 20491656 | Clin. Sci. | 2010 | Borthwick F et al. | Overexpression of STARD3 in human monocyte/macrophages induces an anti-atherogenic lipid phenotype. |
| 19136658 | Diabetes | 2009 | Katz R et al. | Relationship of metabolic syndrome with incident aortic valve calcium and aortic valve calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA). |
| 28161398 | EBioMedicine | 2017 | Shen C et al. | Angiotensin-II-induced Muscle Wasting is Mediated by 25-Hydroxycholesterol via GSK3β Signaling Pathway. |
| 27999160 | MBio | 2016 | Shrivastava-Ranjan P et al. | 25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation. |
| 27600825 | Am. J. Physiol. Endocrinol. Metab. | 2016 | Ou ZJ et al. | 25-Hydroxycholesterol impairs endothelial function and vasodilation by uncoupling and inhibiting endothelial nitric oxide synthase. |
| 27155346 | J. Steroid Biochem. Mol. Biol. | 2017 | Bah SY et al. | Immune oxysterols: Role in mycobacterial infection and inflammation. |