7-Ketocholesterol
7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
References related to abnormalities published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 18802115 | J. Immunol. | 2008 | Nochi H et al. | Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells. |
| 15364622 | Cardiovasc. Res. | 2004 | Seye CI et al. | 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. |
| 18936140 | Invest. Ophthalmol. Vis. Sci. | 2009 | Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. |
| 20554621 | Invest. Ophthalmol. Vis. Sci. | 2010 | Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. |
| 18245064 | Cardiovasc. Res. | 2008 | Hans CP et al. | Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability. |
| 17846428 | Proc. Natl. Acad. Sci. U.S.A. | 2007 | Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. |
| 17122150 | Invest. Ophthalmol. Vis. Sci. | 2006 | Luthra S et al. | Activation of caspase-8 and caspase-12 pathways by 7-ketocholesterol in human retinal pigment epithelial cells. |
| 21144857 | Front Neuroendocrinol | 2011 | Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. |
| 20443782 | Clin. Sci. | 2010 | Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. |
| 18390616 | Biophys. J. | 2008 | Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. |
| 17709641 | Circulation | 2007 | Myoishi M et al. | Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. |
| 11256965 | Biochem. J. | 2001 | Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. |
| 25186795 | Circ. Res. | 2014 | Rao X et al. | CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. |