26-Hydroxycholesterol

26-Hydroxycholesterol is a lipid of Sterol Lipids (ST) class. 26-hydroxycholesterol is associated with abnormalities such as Cardiovascular Diseases, Vascular Diseases, Metabolic syndrome, Obesity and Fatty Streak, Arterial. The involved functions are known as Oxidation, phospholipase activity, glucose metabolism, Binding (Molecular Function) and Regulation. 26-hydroxycholesterol often locates in Immune system, Body tissue, Extracellular, Protoplasm and Back. The associated genes with 26-Hydroxycholesterol are Homologous Gene, chylomicron remnant, Receptor Gene, Alleles and D3 compound. The related lipids are 27-hydroxycholesterol, Hydroxycholesterols, Lysophosphatidylcholines, Total cholesterol and Lipopolysaccharides. The related experimental models are Knock-out and Transgenic Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
20227267	Prostaglandins Leukot. Essent. Fatty Acids	2010 Apr-Jun	Vallim T and Salter AM	Regulation of hepatic gene expression by saturated fatty acids.
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20185735	Diabetes Care	2010	Seet RC et al.	Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.
28213512	J. Exp. Med.	2017	Ismail MA et al.	27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation.
27036870	Am. J. Physiol. Lung Cell Mol. Physiol.	2016	Hashimoto Y et al.	27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells.
26563834	J. Steroid Biochem. Mol. Biol.	2016	Umetani M	Re-adopting classical nuclear receptors by cholesterol metabolites.
25458418	Trends Endocrinol. Metab.	2014	Nelson ER et al.	Cholesterol and breast cancer pathophysiology.
24954418	Cell Metab.	2014	Umetani M et al.	The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha.