7-Dehydrocholesterol

7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
20501590	Development	2010	Niwa R et al.	Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the 'Black Box' of the ecdysteroid biosynthesis pathway.
23144252	J. Bacteriol.	2013	Shimomura H et al.	Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation.
22106170	Drug Metab. Dispos.	2012	Tuckey RC et al.	Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.
22494826	Lancet	2012	Manaseki-Holland S et al.	Effect on the incidence of pneumonia of vitamin D supplementation by quarterly bolus dose to infants in Kabul: a randomised controlled superiority trial.
21799019	J. Biol. Chem.	2011	Wu LC	Immunoglobulin E receptor signaling and asthma.
21441443	Diabetes	2011	Cooper JD et al.	Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes.
20018479	J. Autoimmun.	2010	Maverakis E et al.	Light, including ultraviolet.
12070263	J. Med. Genet.	2002	Waye JS et al.	Smith-Lemli-Opitz syndrome: carrier frequency and spectrum of DHCR7 mutations in Canada.
27162362	Proc. Natl. Acad. Sci. U.S.A.	2016	Sever N et al.	Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.
26854824	Exp. Eye Res.	2016	Pfeffer BA et al.	Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density.
26214382	J. Invest. Dermatol.	2015	Xue Y et al.	Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism.