Ergosterol

Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
20164172	J. Biol. Chem.	2010	Shimada H and Rajagopalan LE	Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65.
11483507	EMBO J.	2001	Kato M and Wickner W	Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion.
21135205	Proc. Natl. Acad. Sci. U.S.A.	2010	Becker JM et al.	Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model.
22106303	Proc. Natl. Acad. Sci. U.S.A.	2012	Yasmin S et al.	Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
18310042	Microbiology (Reading, Engl.)	2008	Oliver BG et al.	Tetracycline alters drug susceptibility in Candida albicans and other pathogenic fungi.
16857942	Science	2006	Selmecki A et al.	Aneuploidy and isochromosome formation in drug-resistant Candida albicans.
16510520	J. Exp. Bot.	2006	Rossard S et al.	Early changes in membrane permeability, production of oxidative burst and modification of PAL activity induced by ergosterol in cotyledons of Mimosa pudica.
18757808	Microbiology (Reading, Engl.)	2008	Hoot SJ et al.	Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms.
22247448	Clin. Infect. Dis.	2012	Lewis RE et al.	How does antifungal pharmacology differ for mucormycosis versus aspergillosis?
24356967	J. Biol. Chem.	2014	Yadav B et al.	First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.
27166810	Biophys. J.	2016	Hung WC et al.	Comparative Study of the Condensing Effects of Ergosterol and Cholesterol.
26908577	MBio	2016	Song J et al.	The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility.
26588567	Biophys. J.	2015	Fiedler S and Heerklotz H	Vesicle Leakage Reflects the Target Selectivity of Antimicrobial Lipopeptides from Bacillus subtilis.
26496686	Chem. Biol.	2015	Leaver DJ et al.	Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.
26116701	FASEB J.	2015	Mathur R et al.	Elevated ergosterol protects Leishmania parasites against antimony-generated stress.
25424002	J. Lipid Res.	2015	Haubrich BA et al.	Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.
24627128	J. Lipid Res.	2014	Fügi MA et al.	Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.