lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
26037280 | Endocr. Relat. Cancer | 2015 | Benesch MG et al. | Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer. |
27544588 | Bioorg. Med. Chem. | 2016 | Ragle LE et al. | Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition. |
28588064 | EMBO J. | 2017 | Aikawa S et al. | Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. |
27641493 | Neuron | 2016 | Cheng J et al. | Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. |
27453502 | Dev. Cell | 2016 | Liu X et al. | PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. |
27401461 | Physiol Rep | 2016 | Sweat RS et al. | Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model. |
27050949 | Stem Cell Reports | 2016 | Walker TL et al. | Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells. |
27006447 | FASEB J. | 2016 | Black KE et al. | Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. |
26671989 | EMBO Mol Med | 2016 | Vogt J et al. | Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. |
26597701 | Biochim. Biophys. Acta | 2016 | Nan L et al. | Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration. |
26476080 | Neoplasia | 2015 | Mukherjee A et al. | Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells. |
26345369 | J. Cell. Sci. | 2015 | Yukiura H et al. | LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells. |
26180199 | J. Neurosci. | 2015 | Santos-Nogueira E et al. | Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury. |
26101324 | J. Immunol. | 2015 | McArthur S et al. | Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. |
26079546 | Exp. Mol. Pathol. | 2015 | Ayasolla KR et al. | Tubular cell phenotype in HIV-associated nephropathy: role of phospholipid lysophosphatidic acid. |
26041536 | J. Immunol. | 2015 | Causton B et al. | CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. |
25855080 | Am. J. Physiol., Cell Physiol. | 2015 | No YR et al. | Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. |
25852197 | Development | 2015 | Sheng X et al. | Lysophosphatidic acid signalling in development. |
25825155 | Exp. Cell Res. | 2015 | Mueller P et al. | Lysophospholipid mediators in the vasculature. |
25695267 | Neuron | 2015 | Yung YC et al. | Lysophosphatidic Acid signaling in the nervous system. |
25555354 | Prostaglandins Leukot. Essent. Fatty Acids | 2015 | Block RC et al. | The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. |
25499971 | Exp. Cell Res. | 2015 | Kihara Y et al. | Lysophospholipid receptors in drug discovery. |
25451317 | Cancer Lett. | 2015 | Ward JD et al. | LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix. |
25433271 | Exp. Cell Res. | 2015 | Yun CC and Kumar A | Diverse roles of LPA signaling in the intestinal epithelium. |
25277122 | Blood | 2014 | Leblanc R et al. | Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. |
24750398 | HPB (Oxford) | 2014 | Simo KA et al. | Altered lysophosphatidic acid (LPA) receptor expression during hepatic regeneration in a mouse model of partial hepatectomy. |
24455753 | Cancer Immunol Res | 2013 | Oda SK et al. | Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. |
24445011 | J. Formos. Med. Assoc. | 2014 | Wang CY et al. | Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts. |