2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

References related to abnormalities published in Others

PMID	Journal	Published Date	Author	Title
26956082	Biochim. Biophys. Acta	2016	Leishman E et al.	Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.
26724516	Mol. Cell. Endocrinol.	2016	González-Mariscal I et al.	Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice.
26180248	J. Nutr.	2015	Mennella I et al.	Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans.
25877930	J. Leukoc. Biol.	2015	Turcotte C et al.	Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.
25489086	Proc. Natl. Acad. Sci. U.S.A.	2014	Morena M et al.	Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
25304184	Pharmacol. Res.	2014	Khasabova IA et al.	JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy.
24704332	Int. J. Infect. Dis.	2014	Sun LJ et al.	Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication.
25384424	FASEB J.	2015	Alhouayek M et al.	N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis.
27133395	Gastroenterology	2016	Sharkey KA and Wiley JW	The Role of the Endocannabinoid System in the Brain-Gut Axis.
26584135	Atherosclerosis	2016	Vujic N et al.	Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
26212325	Cell Rep	2015	Viader A et al.	Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.
26037800	Neuroscience	2015	Hutch CR et al.	An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction.
25776459	J. Nutr. Biochem.	2015	Midtbø LK et al.	Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice.
25378159	J. Neurosci.	2014	Zhang J et al.	Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease.
24548820	Pharmacol. Res.	2014	Stanley CP and O'Sullivan SE	Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.