DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

References related to abnormalities published in Others


PMIDJournalPublished DateAuthorTitle
10476811Invest. Ophthalmol. Vis. Sci.1999Chen H et al.Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs.
10454450Hypertension1999Mori TA et al.Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans.
11274240J. Am. Soc. Nephrol.2001Donadio JV et al.A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy.
11352806Am. J. Physiol. Gastrointest. Liver Physiol.2001Wang H et al.Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes.
12234824Am. J. Physiol. Heart Circ. Physiol.2002Goel DP et al.Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange.
12521943Am. J. Physiol. Heart Circ. Physiol.2003Rousseau D et al.Dietary n-3 PUFAs affect the blood pressure rise and cardiac impairments in a hyperinsulinemia rat model in vivo.
12912821Circulation2003Dallongeville J et al.Fish consumption is associated with lower heart rates.
10899039Am. J. Physiol. Heart Circ. Physiol.2000Xiao YF et al.Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels.
10982541Circulation2000Mori TA et al.Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men.
20732876J. Biol. Chem.2010Arnold C et al.Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.
20702831Invest. Ophthalmol. Vis. Sci.2010Matesanz N et al.Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells.
20713476Pediatrics2010Murakami K et al.Fish and n-3 polyunsaturated fatty acid intake and depressive symptoms: Ryukyus Child Health Study.
21653234J. Leukoc. Biol.2011Palmer CD et al.17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.
21367920Am. J. Physiol. Renal Physiol.2011Diaz Encarnacion MM et al.n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells.
21421544Carcinogenesis2011Weylandt KH et al.Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α.
21478260FASEB J.2011Hellmann J et al.Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice.
20833872FASEB J.2011Chen P et al.Poxytrins, a class of oxygenated products from polyunsaturated fatty acids, potently inhibit blood platelet aggregation.
21156816J. Pharmacol. Exp. Ther.2011Li X et al.Docosahexanoic acid-induced coronary arterial dilation: actions of 17S-hydroxy docosahexanoic acid on K+ channel activity.
19234220J. Immunol.2009Hassan IR and Gronert KAcute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1.
19211925FASEB J.2009González-Périz A et al.Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins.
19029136Cardiovasc. Res.2009Li GR et al.Omega-3 polyunsaturated fatty acids inhibit transient outward and ultra-rapid delayed rectifier K+currents and Na+current in human atrial myocytes.
19050288J. Immunol.2008Kasuga K et al.Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.
19443724Invest. Ophthalmol. Vis. Sci.2009Tian H et al.Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions.
19453514FEMS Microbiol. Lett.2009Orikasa Y et al.pfaB products determine the molecular species produced in bacterial polyunsaturated fatty acid biosynthesis.
19508997Br J Ophthalmol2009Chiu CJ et al.Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?
19638488Cancer Prev Res (Phila)2009Giros A et al.Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic.
19407006Invest. Ophthalmol. Vis. Sci.2009Jin Y et al.Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators.
19433614Am. J. Epidemiol.2009Arsenault LN et al.Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementia.
19380752JPEN J Parenter Enteral Nutr2009 Jul-AugOz HS et al.Nutrition intervention: a strategy against systemic inflammatory syndrome.
20368275J. Immunol.2010Halade GV et al.Docosahexaenoic acid-enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus-prone mice.
19797232Invest. Ophthalmol. Vis. Sci.2010Abrahan CE et al.Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors.
19890019FASEB J.2010Gleissman H et al.Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
20463020J. Biol. Chem.2010Vecchio AJ et al.Structural basis of fatty acid substrate binding to cyclooxygenase-2.
20624993J. Pharmacol. Exp. Ther.2010Khairallah RJ et al.Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium.
20587795Diabetes2010Byeon SH and Chu YKComment on: Tikhonenko et al. (2010) Remodeling of retinal fatty acids in an animal model of diabetes: a decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4. Diabetes;59:219-227.
20551373Circ Cardiovasc Qual Outcomes2010Pottala JV et al.Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study.
20194532Mol. Pharmacol.2010Sharma NP et al.Asymmetric acetylation of the cyclooxygenase-2 homodimer by aspirin and its effects on the oxygenation of arachidonic, eicosapentaenoic, and docosahexaenoic acids.
20097770Am. J. Physiol. Heart Circ. Physiol.2010Billman GE et al.Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.
21753804Am. J. Hypertens.2011Liu JC et al.Long-chain omega-3 fatty acids and blood pressure.
21757663Stroke2011Sekikawa A et al.Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness.
17962433Invest. Ophthalmol. Vis. Sci.2007Bazan NGHomeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.
17962470Invest. Ophthalmol. Vis. Sci.2007Chucair AJ et al.Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid.
17623719Nephrol. Dial. Transplant.2007Saifullah A et al.Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study.
17670935Proc. Natl. Acad. Sci. U.S.A.2007Mukherjee PK et al.Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis.
17699310Clin J Am Soc Nephrol2006Donadio JV et al.Is body size a biomarker for optimizing dosing of omega-3 polyunsaturated fatty acids in the treatment of patients with IgA nephropathy?
18353804Am. J. Epidemiol.2008Oken E et al.Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort.
18285331J. Biol. Chem.2008Milne GL et al.Human biochemistry of the isoprostane pathway.
16216871J. Biol. Chem.2005Ariel A et al.The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering.
16299163Drug Metab. Dispos.2006Hirunpanich V et al.Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.
15655248J. Biol. Chem.2005Marszalek JR et al.Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism.
15708862J. Biol. Chem.2005Gronert K et al.A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense.
15987770Am. J. Physiol., Cell Physiol.2005Guizy M et al.{Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels.
16424216J. Immunol.2006Serhan CN et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.
16473961Am. J. Physiol. Heart Circ. Physiol.2006Pfrommer CA et al.Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis.
17053155Clin. Chem.2006Cao J et al.Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids.
17122401Appl. Environ. Microbiol.2007Okuyama H et al.Bacterial genes responsible for the biosynthesis of eicosapentaenoic and docosahexaenoic acids and their heterologous expression.
17056514J. Immunol.2006Duffield JS et al.Resolvin D series and protectin D1 mitigate acute kidney injury.
17056761FASEB J.2006González-Périz A et al.Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.
17182589J. Immunol.2007Levy BD et al.Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.
17244615J. Biol. Chem.2007Sun YP et al.Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation.
18641046Eur. Heart J.2008Streppel MT et al.Long-term fish consumption and n-3 fatty acid intake in relation to (sudden) coronary heart disease death: the Zutphen study.
18559988FASEB J.2008Merched AJ et al.Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.
22013115J. Immunol.2011Titos E et al.Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype.
22282329Circulation2012Wu JH et al.Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study.
22332072Adv Nutr2011Kalupahana NS et al.(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights.
22332096Adv Nutr2012Swanson D et al.Omega-3 fatty acids EPA and DHA: health benefits throughout life.
22923273Circ Arrhythm Electrophysiol2012Ramadeen A et al.Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation.
21724996J. Immunol.2011Bento AF et al.Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice.
22802419J. Immunol.2012Rogerio AP et al.Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.
22016541J. Neurosci.2011Park CK et al.Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.
22844113J. Immunol.2012Clària J et al.Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.
23460284Hypertension2013Skilton MR et al.High intake of dietary long-chain ω-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008.
23103493Am. J. Physiol. Heart Circ. Physiol.2013Galvao TF et al.Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.
23174566Am. J. Physiol., Cell Physiol.2013Larson MK et al.Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.
24458713Arterioscler. Thromb. Vasc. Biol.2014Shao Z et al.Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report.
24228198Adv Nutr2013Cederholm T et al.ω-3 fatty acids in the prevention of cognitive decline in humans.